BZs (Benzodiazepine) are chiral molecules by virtue of their nonplanar seven-membered ring. Due to the lack of a center of asymmetry, the BZ molecule populates two mirror-image conformations in equally. The biological activities of differ substantially owing to their differential recognition by the receptor sites. By studying the receptor binding of successively substituted derivatives, one witnesses the simultaneous operation of steric and conformational effects that help unravel properties of the BZ receptor cavity functioning through chiral recognition.
|Number of pages||2|
|Journal||Journal of Molecular Graphics|
|Publication status||Published - Jun 1 1989|
|Event||Conference Papers from the Symposium on Molecular Recognition: Its Role in Chemistry and Biochemistry - Sopron, Hung, USA|
Duration: Aug 24 1988 → Aug 27 1988
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