Chiral recognition by central benzodiazepine receptors

M. Simonyi, G. Maksay, I. Kovacs, Zs Tegyey, L. Parkaanyi, A. Kalman, L. Otvos

Research output: Contribution to journalConference article

Abstract

BZs (Benzodiazepine) are chiral molecules by virtue of their nonplanar seven-membered ring. Due to the lack of a center of asymmetry, the BZ molecule populates two mirror-image conformations in equally. The biological activities of differ substantially owing to their differential recognition by the receptor sites. By studying the receptor binding of successively substituted derivatives, one witnesses the simultaneous operation of steric and conformational effects that help unravel properties of the BZ receptor cavity functioning through chiral recognition.

Original languageEnglish
Pages (from-to)93-94
Number of pages2
JournalJournal of Molecular Graphics
Volume7
Issue number2
Publication statusPublished - Jun 1 1989
EventConference Papers from the Symposium on Molecular Recognition: Its Role in Chemistry and Biochemistry - Sopron, Hung, USA
Duration: Aug 24 1988Aug 27 1988

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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