Childhood cancer in relation to infections in the community during pregnancy and around the time of birth

T. Nyári, Heather O. Dickinson, Louise Parker

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In a retrospective cohort study of 404,106 live births in the northern region of England, 1975-1986, we investigated whether higher levels of community infections during the mother's pregnancy and in early life were risk factors for cancer, by diagnostic group (leukaemia and non-Hodgkin's lymphoma, Hodgkin's disease, brain/spinal tumours, neuroblastoma, other tumours), diagnosed 1975-2001 under age 15 years. Logistic regression was used to relate risk to measures of community infections (measles, respiratory and other infections) in 3 prenatal and 2 postnatal quarters. There was an increased risk of Hodgkin's disease among children exposed around birth to higher levels of measles (odds ratio for trend = 2.3, 95% confidence interval 1.3-4.2, p = 0.01). For other diagnostic groups, there was no consistent evidence of an association between risk and exposure to infections. Although the significant association observed for Hodgkin's disease may be a chance finding, consequent to multiple hypothesis testing or the ecologic nature of the study, it is consistent with other recent epidemiologic results suggesting that the risk of Hodgkin's disease may be associated with exposure to infections.

Original languageEnglish
Pages (from-to)772-777
Number of pages6
JournalInternational Journal of Cancer
Volume104
Issue number6
DOIs
Publication statusPublished - May 10 2003

Fingerprint

Hodgkin Disease
Parturition
Pregnancy
Measles
Infection
Neoplasms
Live Birth
Neuroblastoma
Brain Neoplasms
Respiratory Tract Infections
England
Non-Hodgkin's Lymphoma
Leukemia
Cohort Studies
Retrospective Studies
Logistic Models
Odds Ratio
Mothers
Confidence Intervals

Keywords

  • Children's cancer
  • Epidemiology
  • Infections

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Childhood cancer in relation to infections in the community during pregnancy and around the time of birth. / Nyári, T.; Dickinson, Heather O.; Parker, Louise.

In: International Journal of Cancer, Vol. 104, No. 6, 10.05.2003, p. 772-777.

Research output: Contribution to journalArticle

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