Childhood acute lymphoblastic leukaemia in relation to population mixing around the time of birth in South Hungary

Tibor A. Nyári, Pál Kajtár, Katalin Bartyik, László Thurzó, Louise Parker

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Abstract

In a retrospective epidemiological study of 481,984 live births in South Hungary, we investigated whether higher levels of population mixing around the time of birth is a risk factor for acute lymphoblastic leukemia (ALL) under age 5 years. Poisson regression was used to investigate the relationship between risk of ALL and the population-mixing index based on the number of incomers in each county district for each year, standardized to have a range of 0-1. Among all children, the risk of ALL increased significantly with increasing population mixing around the time of birth (trend across the range of 0-1 RR = 2.1 95% Cl: 1.02-4.44). This effect was more marked for boys (RR = 3.1 95% Cl: 1.13-8.51), which supports a sex-specific effect of exposures on risk of ALL.

Original languageEnglish
Pages (from-to)944-948
Number of pages5
JournalPediatric Blood and Cancer
Volume47
Issue number7
DOIs
Publication statusPublished - Dec 1 2006

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Keywords

  • ALL
  • Epidemiology
  • Infections
  • Population mixing

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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