Childhood acute lymphoblastic leukaemia in relation to population mixing around the time of birth in South Hungary

T. Nyári, Pál Kajtár, Katalin Bartyik, L. Thurzó, Louise Parker

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In a retrospective epidemiological study of 481,984 live births in South Hungary, we investigated whether higher levels of population mixing around the time of birth is a risk factor for acute lymphoblastic leukemia (ALL) under age 5 years. Poisson regression was used to investigate the relationship between risk of ALL and the population-mixing index based on the number of incomers in each county district for each year, standardized to have a range of 0-1. Among all children, the risk of ALL increased significantly with increasing population mixing around the time of birth (trend across the range of 0-1 RR = 2.1 95% Cl: 1.02-4.44). This effect was more marked for boys (RR = 3.1 95% Cl: 1.13-8.51), which supports a sex-specific effect of exposures on risk of ALL.

Original languageEnglish
Pages (from-to)944-948
Number of pages5
JournalPediatric Blood and Cancer
Volume47
Issue number7
DOIs
Publication statusPublished - Dec 2006

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Hungary
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Parturition
Population
Live Birth
Epidemiologic Studies
Retrospective Studies

Keywords

  • ALL
  • Epidemiology
  • Infections
  • Population mixing

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Childhood acute lymphoblastic leukaemia in relation to population mixing around the time of birth in South Hungary. / Nyári, T.; Kajtár, Pál; Bartyik, Katalin; Thurzó, L.; Parker, Louise.

In: Pediatric Blood and Cancer, Vol. 47, No. 7, 12.2006, p. 944-948.

Research output: Contribution to journalArticle

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