Chemotherapeutic sensitivity of liver metastases from intrasplenically-growing Lewis lung tumor

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Abstract

A recently developed metastatic tumor model was used to study the therapeutic response of liver metastases derived from intrasplenically growing LLT. Treatment was performed on the day following surgical removal of the 'primary tumor'. The life-span of tumor-bearing animals and the number and volume of liver metastases were measured. Cyclophosphamide and 13324 (a new bifunctional nitrosoureido derivative) proved to be most effective. Some other drugs (5-FU, McCCNU, Lycurim) showed a temporary regression in the formation of macrometastases without influencing the life-span. Adriamycin was slightly more effective given i.p. than i.v.

Original languageEnglish
Pages (from-to)341-347
Number of pages7
JournalClinical & Experimental Metastasis
Volume1
Issue number4
DOIs
Publication statusPublished - Oct 1 1983

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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