Chemotaxis of freshly separated and cultured human keratinocytes

R. GYULAI, J. HUNYADI, A. KENDERESSY‐SZABÓ, L. KEMÉNY, A. DOBOZY

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

It is generally accepted that keratinocyte migration plays a critical role in the process of wound healing. A study was therefore made of the migratory response of freshly separated and cultured human keratinocytes to factors with chemotactic properties for a variety of cells. Interleukin‐lα (IL‐lα), interferon‐γ (IFN‐γ), interleukin‐8 (IL‐8), and tumour necrosis factor α (TNF‐α) were tested for their chemotactic effectiveness in a modified Boydcn chamber assay. IFN‐γ, IL‐lα and IL‐8 were demonstrated to serve as chemoattractants for freshly separated keratinocytes. For cultured cells, however, only IFN‐γ was found to display chemotactic properties. The findings demonstrate that there is significant difference between the chemotactic behaviour of freshly separated and cultured cells.

Original languageEnglish
Pages (from-to)309-311
Number of pages3
JournalClinical and Experimental Dermatology
Volume19
Issue number4
DOIs
Publication statusPublished - Jul 1994

ASJC Scopus subject areas

  • Dermatology

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