Chemotaxis and chemotactic selection induced with cytokines (IL-8, RANTES and TNF-α) in the unicellular Tetrahymena pyriformis

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50 Citations (Scopus)

Abstract

Three representative cytokines interleukin (IL-8), RANTES and tumour necrosis factor α (TNF-α) have a concentration-dependent chemotactic effect on the unicellular Tetrahymena. Maximal effective concentrations of IL-8 (1 ng/ml) and RANTES (75 ng/ml) are in the same range as in mammals, which indicates an evolutionary background of physiological effects elicited. Progeny generations of cells selected for their affinity to cytokines (IL-8 and TNF-α) show an enhanced positive chemosensory reaction to the cytokines. The changed reaction of these cells to the chemoattraction of the culturing medium was also observed. The results call attention to the presence of cytokine-dependent processes at a low phylogenetic level.

Original languageEnglish
Pages (from-to)481-486
Number of pages6
JournalCytokine
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 1998

Keywords

  • Chemotaxis
  • Cytokine
  • Selection
  • Tetrahymena

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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