Chemotactic response of unicellular tetrahymena to a leukocyte attractant peptide and its repellent derivate: evolutionary conclusions.

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Abstract

Chemotactic properties of the leukocyte chemoattractant N-formyl-Norleucine-Leucine-Phenylalanine (NLP) and its antagonist N-t-BOC-Norleucine-Leucine-Phenylalanine (BOC-NLP) were investigated in unicellular Tetrahymena pyriformis cells. NLP express its attractant character in a two-peak profile of concentration course (maximum at 10-8-10-7 M and 10-11 M) while BOC-NLP has a constant repellent character (maximum at 10-12 M). The observed homology of action concurs with our theory about the wide evolutionary background of signal molecules and receptors.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalCell biology international
Volume18
Issue number2
DOIs
Publication statusPublished - Feb 1 1994

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ASJC Scopus subject areas

  • Cell Biology

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