Chemoradiotherapy with 5-fluorouracil/leucovorin, surgery and adjuvant chemotherapy for locally advanced rectal cancer

M. Baur, M. Horvath, S. Stättner, A. Schratter-Sehn, B. Horvath, F. Sellner, M. Hudec, M. Klimpfinger, C. Dittrich, J. Karner

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Abstract

The aim of this study was to demonstrate a pathologic complete response (pCRCR) rate of at least 10% with an acceptable toxicity achieved by preoperative chemoradiotherapy with 5-fluorouracil (5-FU)/leucovorin in patients with locally advanced rectal cancer. Patients were treated by radiotherapy targeting 50 Gy and 5-FU/leucovorin intravenously during the 1st, 4th and 7th week after start of radiotherapy followed by surgery and adjuvant chemotherapy. In 71 evaluable patients, the pCRCR rate was 14.1% (95% CI, 6.0-22.2); the local relapse rate, 6.1%; the 5-year disease-free survival, 54% and the overall 5-year survival, 68%. The most severe adverse events were neutropenia (17%), diarrhoea (17%), infection (8%) and fatal cardiovascular function (1%). This therapy yielded a high rate of pCRCR, a low rate of local relapse and a long disease-free and overall survival. To increase its feasibility, radiation dose reduction to 45 Gy and administration of only two preoperative cycles of chemotherapy is recommended.

Original languageEnglish
Pages (from-to)189-194
Number of pages6
JournalOncology Letters
Volume1
Issue number1
DOIs
Publication statusPublished - Jan 1 2010

Keywords

  • 5-fluorouracil
  • Distal rectal cancer
  • Leucovorin
  • Local relapse rate
  • Locally advanced rectal cancer
  • Preoperative chemoradiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Baur, M., Horvath, M., Stättner, S., Schratter-Sehn, A., Horvath, B., Sellner, F., Hudec, M., Klimpfinger, M., Dittrich, C., & Karner, J. (2010). Chemoradiotherapy with 5-fluorouracil/leucovorin, surgery and adjuvant chemotherapy for locally advanced rectal cancer. Oncology Letters, 1(1), 189-194. https://doi.org/10.3892/ol_00000035