Chemopreventive effect of Panax ginseng

T. Varjas, G. Nowrasteh, F. Budán, E. Nadasi, G. Horváth, S. Makai, T. Gracza, J. Cseh, I. Ember

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Asian ginseng (Panax ginseng C. A. Meyer) has been used in Chinese medicine for two thousand years. The root of ginseng contains several saponins (ginsenosides) which are biologically active compounds. Individual ginsenosides suppress tumor cell growth, induce cell differentiation, regulate apoptosis and inhibit metastasis formation. The aim of this study was to evaluate its chemo-preventive effects in an animal test model, through its regulatory effects on apoptosis and the cell cycle. The expression of genes (Bcl-2, Bcl-x and Cyclin D1) which affect apoptosis were examined, in different organs of animals which had consumed a ginseng-containing diet in the presence of a known carcinogen (DMBA). The pattern of gene expression was determined by Q-RT-PCR. The increase of antiapoptotic gene expression after carcinogenic exposure was suppressed by consumption of ginseng which promoted apoptosis. The population is exposed to numerous physical and chemical insults in the modern environment and these include compounds which are known carcinogens. Research has shown that it is possible to interfere with the multi-step process of carcinogenesis through the use of compounds with chemo-preventive effects, such as the inhibition of the activation of antiapoptotic genes. These results support the efficacy of ginseng-containing diets and dietary supplements in the prevention of cancerous diseases.

Original languageEnglish
Pages (from-to)1399-1403
Number of pages5
JournalPhytotherapy Research
Volume23
Issue number10
DOIs
Publication statusPublished - Oct 2009

Fingerprint

Panax
Apoptosis
Ginsenosides
Carcinogens
Diet
Animal Structures
bcl-2 Genes
Gene Expression
9,10-Dimethyl-1,2-benzanthracene
Cyclin D1
Saponins
Dietary Supplements
Transcriptional Activation
Cell Differentiation
Cell Cycle
Carcinogenesis
Animal Models
Medicine
Neoplasm Metastasis
Polymerase Chain Reaction

Keywords

  • Apoptosis
  • Chemoprevention
  • Gene expression
  • Panax ginseng

ASJC Scopus subject areas

  • Pharmacology

Cite this

Varjas, T., Nowrasteh, G., Budán, F., Nadasi, E., Horváth, G., Makai, S., ... Ember, I. (2009). Chemopreventive effect of Panax ginseng. Phytotherapy Research, 23(10), 1399-1403. https://doi.org/10.1002/ptr.2786

Chemopreventive effect of Panax ginseng. / Varjas, T.; Nowrasteh, G.; Budán, F.; Nadasi, E.; Horváth, G.; Makai, S.; Gracza, T.; Cseh, J.; Ember, I.

In: Phytotherapy Research, Vol. 23, No. 10, 10.2009, p. 1399-1403.

Research output: Contribution to journalArticle

Varjas, T, Nowrasteh, G, Budán, F, Nadasi, E, Horváth, G, Makai, S, Gracza, T, Cseh, J & Ember, I 2009, 'Chemopreventive effect of Panax ginseng', Phytotherapy Research, vol. 23, no. 10, pp. 1399-1403. https://doi.org/10.1002/ptr.2786
Varjas T, Nowrasteh G, Budán F, Nadasi E, Horváth G, Makai S et al. Chemopreventive effect of Panax ginseng. Phytotherapy Research. 2009 Oct;23(10):1399-1403. https://doi.org/10.1002/ptr.2786
Varjas, T. ; Nowrasteh, G. ; Budán, F. ; Nadasi, E. ; Horváth, G. ; Makai, S. ; Gracza, T. ; Cseh, J. ; Ember, I. / Chemopreventive effect of Panax ginseng. In: Phytotherapy Research. 2009 ; Vol. 23, No. 10. pp. 1399-1403.
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