Chemoprevention and inhibition of P-glycoprotein in cancer cells by Chinese medicinal herbs

Helga Engi, Judit Hohmann, Geng Gang, Rozália Pusztai, Dóra Rédei, Orsolya Kovács, Zsuzsanna Schelz, Joseph Molnár

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Many of the herbal extracts used in the Chinese clinical medical routine inhibit the growth of tumor cells. In the present work, extracts of 12 selected herbs were prepared with methanol, chloroform, ethyl acetate and water, and the effects of these on the multidrug resistance (MDR) and P-glycoprotein of mouse lymphoma cells transfected with the human mdr1 gene and on a human lung alveolar epithelial cell line were investigated. The extracts were tested for antiproliferative effects, and the reversal of MDR in mouse lymphoma cells. The possible chemopreventive effect of the chloroform extracts was studied on the expression of cytomegalovirus (CMV) immediate-early (IE) antigen in human lung cancer cells (A549). The antimicrobial effects of the extracts were tested on some representative micro-organisms. Certain of the chloroform extracts of the plant materials were the most effective compounds on the reversal of MDR. Two of the chloroform extracts enhanced the antiproliferative effect of doxorubicin on MDR mouse lymphoma cells. The selected extracts did not show any antibacterial effect with the agar diffusion method. Certain chloroform extracts decreased the intermediate IE antigen expression of CMV in A459 cells.

Original languageEnglish
Pages (from-to)1671-1676
Number of pages6
JournalPhytotherapy Research
Volume22
Issue number12
DOIs
Publication statusPublished - Dec 1 2008

Keywords

  • Antitumor promoters
  • Human cytomegalovirus
  • Immediate-early antigen expression
  • Multidrug resistance
  • P-glycoprotein
  • Traditional chinese medicine (TCM)

ASJC Scopus subject areas

  • Pharmacology

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