Chemokines and angiogenesis in rheumatoid arthritis

Zoltan Szekanecz, Angela Pakozdi, Agnes Szentpetery, Timea Besenyei, Alisa E. Koch

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

In rheumatoid arthritis, chemokines mediate the migration of inflammatory leukocytes into the synovium. Among the four known chemokine families, CXC, CC chemokines and fractalkine seem to be of outstanding importance in this process. Angiogenesis, the formation of new vessels, is also important during the perpetuation of inflammation underlying rheumatoid arthritis. In this review, authors discuss the role of the most important chemokines and chemokine repetors in arthritis-associated neovascularization. The process and regulation of angiogenesis are described in this context as well. Apart from discussing the pathogenic role of chemokines and chemokine receptors in arthritic vessel formation, authors also review the important relevance of chemokines and angiogenesis for therapeutic intervention.

Original languageEnglish
Pages (from-to)44-51
Number of pages8
JournalFrontiers in Bioscience - Elite
Volume1 E
Issue number1
Publication statusPublished - Jan 6 2009

Keywords

  • Angiogenesis
  • Angiogenic mediators
  • Chemokine receptors
  • Chemokines
  • Review
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Szekanecz, Z., Pakozdi, A., Szentpetery, A., Besenyei, T., & Koch, A. E. (2009). Chemokines and angiogenesis in rheumatoid arthritis. Frontiers in Bioscience - Elite, 1 E(1), 44-51.