Chemokines and angiogenesis

Z. Szekanecz, Alisa E. Koch

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Chemokines mediate the ingress of leukocytes, including neutrophils and monocytes, into the inflamed synovium. Among the four known chemokine families, C-X-C and C-C chemokines seem to be of outstanding importance in this process. Angiogenesis, the formation of new vessels, is also important in the pathogenesis of rheumatoid arthritis. In this review, the authors discuss the role of the most important chemokines in the pathogenesis of rheumatoid synovitis. The most relevant angiogenic factors and angiogenesis inhibitors involved in rheumatoid arthritis are also discussed. Because certain chemokines may also play a role in neovascularization, chemokines and the process of angiogenesis are described in this context as well. Apart from discussing the pathogenic role of these factors, the authors also review the important relevance of chemokines and angiogenesis for therapeutic intervention.

Original languageEnglish
Pages (from-to)202-208
Number of pages7
JournalCurrent Opinion in Rheumatology
Volume13
Issue number3
DOIs
Publication statusPublished - 2001

Fingerprint

Chemokines
Angiogenesis Inhibitors
Rheumatoid Arthritis
CXC Chemokines
CC Chemokines
Synovitis
Synovial Membrane
Angiogenesis Inducing Agents
Monocytes
Neutrophils
Leukocytes
Therapeutics

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Chemokines and angiogenesis. / Szekanecz, Z.; Koch, Alisa E.

In: Current Opinion in Rheumatology, Vol. 13, No. 3, 2001, p. 202-208.

Research output: Contribution to journalArticle

Szekanecz, Z. ; Koch, Alisa E. / Chemokines and angiogenesis. In: Current Opinion in Rheumatology. 2001 ; Vol. 13, No. 3. pp. 202-208.
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