Chemo-radiotherapy in locally advanced squamous cell oesophageal cancer-are upper third tumours more esponsive?

Andras Papp, Laszlo Cseke, Robert Farkas, Gabor Pavlovics, Gabor Horvath, Gabor Varga, A. Szigeti, S. Bellyei, Sandor Marton, Laszlo Poto, Katalin Kalmar, Andras Vereczkei, Eva Pozsgai, O. Horvath

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Before neoadjuvant therapy was widely applied, the prognosis of oesophageal cancer had been considered dependent on the location of the tumor, i.e. upper third cancers had had the worst prognosis. The aim of this retrolective study was to prove the efficiency of the neoadjuvant treatment, and to compare the response of esophageal cancer in different locations. Between January 1998 and September 2005, 102 patients with locally advanced squamous cell oesophageal cancer received preoperative chemo-radiotherapy. In 40 cases the tumor was located in the upper third and in 62 cases in the middle third of the oesophagus. After a four-week-long treatment free period restaging was carried out and patients considered resectable were submitted to surgery. From 40 patients with upper third oesophageal cancer 28 underwent oesophageal resection or pharyngo-laryngectomy. Thiry-five percent a complete histopathological remission was observed. From 62 patients with middle third oesophageal cancer 43 underwent oesophageal resection. Histological examination of the resected specimens documented complete response only in three patients. The median survival and the R0 resection rate were similar in the two groups. Although the resection rate, perioperative morbidity, mortality and the median survival were similar in the two groups, a significantly higher rate of complete response (p

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalPathology and Oncology Research
Volume16
Issue number2
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Squamous Cell Neoplasms
Esophageal Neoplasms
Radiotherapy
Neoadjuvant Therapy
Neoplasms
Laryngectomy
Survival
Esophagus
Morbidity
Mortality

Keywords

  • Complete response
  • Locally advanced tumor
  • Neoadjuvant therapy
  • Squamous cell oesophageal cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Chemo-radiotherapy in locally advanced squamous cell oesophageal cancer-are upper third tumours more esponsive? / Papp, Andras; Cseke, Laszlo; Farkas, Robert; Pavlovics, Gabor; Horvath, Gabor; Varga, Gabor; Szigeti, A.; Bellyei, S.; Marton, Sandor; Poto, Laszlo; Kalmar, Katalin; Vereczkei, Andras; Pozsgai, Eva; Horvath, O.

In: Pathology and Oncology Research, Vol. 16, No. 2, 06.2010, p. 193-200.

Research output: Contribution to journalArticle

Papp, A, Cseke, L, Farkas, R, Pavlovics, G, Horvath, G, Varga, G, Szigeti, A, Bellyei, S, Marton, S, Poto, L, Kalmar, K, Vereczkei, A, Pozsgai, E & Horvath, O 2010, 'Chemo-radiotherapy in locally advanced squamous cell oesophageal cancer-are upper third tumours more esponsive?', Pathology and Oncology Research, vol. 16, no. 2, pp. 193-200. https://doi.org/10.1007/s12253-009-9206-5
Papp, Andras ; Cseke, Laszlo ; Farkas, Robert ; Pavlovics, Gabor ; Horvath, Gabor ; Varga, Gabor ; Szigeti, A. ; Bellyei, S. ; Marton, Sandor ; Poto, Laszlo ; Kalmar, Katalin ; Vereczkei, Andras ; Pozsgai, Eva ; Horvath, O. / Chemo-radiotherapy in locally advanced squamous cell oesophageal cancer-are upper third tumours more esponsive?. In: Pathology and Oncology Research. 2010 ; Vol. 16, No. 2. pp. 193-200.
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