Chemo-enzymatic preparation of hydroxymethyl ketones

Csaba Paizs, Monica Toşa, Cornelia Majdik, Viktória Bódai, Lajos Novák, Florin Dan Irimie, László Poppe

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Abstract

A series of hydroxymethyl ketones 4a-g were obtained from the corresponding halogenomethyl ketones 2a-g via their transformation into acetoxymethyl ketones 3a-g by 18-crown-6 catalysed substitution with NaOAc followed by Novozyme 435™ catalysed ethanolysis. This convenient chemo-enzymatic route provides a mild, heavy-metal-free alternative to the direct α-hydroxylations of methyl ketones 1a-g.

Original languageEnglish
Pages (from-to)2400-2402
Number of pages3
JournalJournal of the Chemical Society. Perkin Transactions 1
Volume21
DOIs
Publication statusPublished - Jan 1 2002

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ASJC Scopus subject areas

  • Chemistry(all)

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