Chemistry of an Unexplored Heterocyclic Ring System: Versatile Synthesis of 5-Aryl-2,3,4-benzothiadiazepine 2,2-dioxides

J. Fetter, Ferenc Bertha, Balázs Molnár, Balázs Volk, Gyula Simig

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The article gives insight into the synthetic approach of a practically new heterocyclic ring system, 2,3,4-benzothiadiazepines. Starting from the easily available phthalides, an efficient synthesis of 5-aryl-2,3,4-benzothiadiazepine 2,2-dioxides is described here. Owing to their close structural similarity to 2,3-benzodiazepines and 2,3-benzodiazepine-4-ones, two well-known bioactive compound families, the new derivatives can be of importance in medicinal chemistry.

Original languageEnglish
Pages (from-to)1136-1142
Number of pages7
JournalJournal of Heterocyclic Chemistry
Volume52
Issue number4
DOIs
Publication statusPublished - Jul 1 2015

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Benzodiazepines
Derivatives
phthalide
Pharmaceutical Chemistry

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Chemistry of an Unexplored Heterocyclic Ring System : Versatile Synthesis of 5-Aryl-2,3,4-benzothiadiazepine 2,2-dioxides. / Fetter, J.; Bertha, Ferenc; Molnár, Balázs; Volk, Balázs; Simig, Gyula.

In: Journal of Heterocyclic Chemistry, Vol. 52, No. 4, 01.07.2015, p. 1136-1142.

Research output: Contribution to journalArticle

Fetter, J. ; Bertha, Ferenc ; Molnár, Balázs ; Volk, Balázs ; Simig, Gyula. / Chemistry of an Unexplored Heterocyclic Ring System : Versatile Synthesis of 5-Aryl-2,3,4-benzothiadiazepine 2,2-dioxides. In: Journal of Heterocyclic Chemistry. 2015 ; Vol. 52, No. 4. pp. 1136-1142.
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