Chemistry and Structure-Activity Relationships of Herbicide Safeners

Tamás Kőmíves, Kriton K. Hatzios

Research output: Contribution to journalArticle

12 Citations (Scopus)


The discovery and commercial success of safeners against thiolcarbamate herbicide injury to corn has stimulated a rapid progress and opened new possibilities for further research and development in the last decade. Compounds with new chemistry, increased efficacy, and a broader selectivity spectrum were synthesized and developed for agricultural use. Structure-activity relationship studies helped to optimize their chemical properties and to understand their biological modes of action. Several examples indicate close similarity between chemical structures possessing herbicidal and safener properties. In some cases this differentiation may be marginal, as shown in crops pretreated with low herbicide dnses leading to safening effects. In other examples, however, structural optima for safening and herbicidal efficacy can be clearly differentiated.

Original languageEnglish
Pages (from-to)798-804
Number of pages7
JournalZeitschrift fur naturforschung - section c journal of biosciences
Issue number9-10
Publication statusPublished - Oct 1 1991


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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