Chemically-modified nanopores for sensing

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Sensing with chemically-modified nanopores is an emerging field that is expected to have major impact on bioanalysis and fundamental understanding of nanoscale chemical interactions down to the single-molecule level. The main strength of nanopore sensing is that it implies the prospect of label-free single-molecule detection by taking advantage of the built-in transport-modulation-based amplification mechanism. At present, fabrication and application of solid-state nanopores are becoming the focus of attention because, compared with their biological counterparts, they offer greater flexibility in terms of shape, size, and surface properties, as well as superior robustness. A breakthrough in label-free nanopore sensing for real-world applications is therefore expected from implementing solid-state nanopores, an area that is still developing. Without claiming comprehensiveness, the focus of this review comprises recent results and trends in nanopore-based sensing (i.e. emerging technologies for fabricating solid-state nanopores, their chemical functionalization, and detection methods for quantitative analysis).

Original languageEnglish
Pages (from-to)627-639
Number of pages13
JournalTrAC - Trends in Analytical Chemistry
Volume27
Issue number7
DOIs
Publication statusPublished - Jul 2008

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Keywords

  • Affinity-type bioassay
  • Bioanalysis
  • Biosensing
  • Chemical sensing
  • Chemically-modified nanopore
  • Label-free single-molecule detection
  • Nanopore sensing
  • Resistive-pulse technique
  • Solid-state nanopore
  • Transport modulation

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Chemically-modified nanopores for sensing. / Gyurcsányi, R.

In: TrAC - Trends in Analytical Chemistry, Vol. 27, No. 7, 07.2008, p. 627-639.

Research output: Contribution to journalArticle

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