Chemically induced carcinogenesis affecting chromatin structure in rat hepatocarcinoma cells

Gyorgy Trencsényi, Pal Kertai, Csilla Somogyi, Gabor Nagy, Zsuzsa Dombradi, Mariann Gacsi, Gaspar Banfalvi

Research output: Contribution to journalArticle

18 Citations (Scopus)


A new, chemically induced animal tumor cell line (HeDe) was established and characterized by its property of causing aggressively growing tumors in specific strain of rats and changes in the chromatin structure. Results show that (1) the nuclear material in nuclei of normal resting (G0) hepatocytes consists mainly of decondensed veil-like chromatin, chromosomes being clustered in six lobular domains; (2) nuclei of HeDe cells contain primarily supercoiled chromatin; or (3) the nuclear material of tumor cells undergoes apoptosis seen as apoptotic bodies. Heterogeneity of chromatin structures was expressed as contour/area ratio and was nine times higher in apoptotic cells and two times higher in tumor cells compared to resting cells.

Original languageEnglish
Pages (from-to)649-655
Number of pages7
JournalDNA and Cell Biology
Issue number9
Publication statusPublished - Sep 1 2007


ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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