MARRUBIUM FAJOK NOVENYKEMIAI VIZSGALATA ADATOK A VII. MAGYAR GYOGYSZERKONYV MARRUBII HERBA CIKKELYEHEZ

Translated title of the contribution: Chemical tests with Marrubium species. Data to Marrubii herba official in Pharmacopoeia Hungarica VII

Erika Telek, László Tóth, Lajos Botz, Imre Máthé

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

About 40 species of the Marrubium genus (Lamiaceae) are known of which 2 species (M. vulgare L. and M. peregrinum L.) and one hybrid (M. x paniculatum Desr.) can be found as native plants in Hungary. The above-ground parts of M. vulgare L. are official in Hungarian Pharmacopoeia VII. Active substances in Marrubii herba are labdane-structured bitter materials. Although the presence of furanic labdane diterpenes in the plant is known, the pharmacopoeia gives only microscopic tests, qualitative tests (for other parts of the plant and foreign organic matter) for the bitter value of Marrubii herba. We have examined the main terpenoid substances isolated with column, gel and preparative layer chromatography. Structure elucidations were performed by means of UV, mass and NMR spectroscopy. We have compared the changes in terpenoid-type compounds (premarrubiin and marrubiin) in plants during the vegetation period; in different Marrubium species and in the different extractions of horehound by means of thin layer chromatography and densitometry. By reason of our results we propose qualitative and quantitative chemical tests for the paragraph of Marrubii herba in Pharmacopoeia Hungarica VII.

Translated title of the contributionChemical tests with Marrubium species. Data to Marrubii herba official in Pharmacopoeia Hungarica VII
Original languageHungarian
Pages (from-to)31-37
Number of pages7
JournalActa pharmaceutica Hungarica
Volume67
Issue number1
Publication statusPublished - Jan 1997

ASJC Scopus subject areas

  • Pharmaceutical Science

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