The role of transforming growth factor beta 1 (TGF-β1) in carcinogenesis is a controversial issue. Certain results suggest a promoter role of this growth factor whilst in other experimental models TGF-β1 seems to inhibit the process of tumorigenesis. In an attempt to resolve this problem, we have performed chemical hepatocarcinogenesis experiments on transgenic mice expressing a high level of active TGF-β1 in their liver. Transgenic production of TGF-β1 did not result in spontaneous tumour formation during our observation period. However, two carcinogens, thioacetamide and N-OH acetylaminofluorene, were more potent in transgenic than in wild-type mice, whereas aflatoxin B1 was equally effective in both groups. Our observations suggest that an increased level of TGF-β1 in the liver does not provide protection against the effect of chemical carcinogens.
- Aflatoxin B1
- Transforming growth factor beta
ASJC Scopus subject areas
- Cancer Research