Chemical hepatocarcinogenesis in transgenic mice overexpressing mature TGFβ-1 in liver

J. Schnur, P. Nagy, A. Sebestyén, Z. Schaff, S. S. Thorgeirsson

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21 Citations (Scopus)

Abstract

The role of transforming growth factor beta 1 (TGF-β1) in carcinogenesis is a controversial issue. Certain results suggest a promoter role of this growth factor whilst in other experimental models TGF-β1 seems to inhibit the process of tumorigenesis. In an attempt to resolve this problem, we have performed chemical hepatocarcinogenesis experiments on transgenic mice expressing a high level of active TGF-β1 in their liver. Transgenic production of TGF-β1 did not result in spontaneous tumour formation during our observation period. However, two carcinogens, thioacetamide and N-OH acetylaminofluorene, were more potent in transgenic than in wild-type mice, whereas aflatoxin B1 was equally effective in both groups. Our observations suggest that an increased level of TGF-β1 in the liver does not provide protection against the effect of chemical carcinogens.

Original languageEnglish
Pages (from-to)1842-1845
Number of pages4
JournalEuropean Journal of Cancer
Volume35
Issue number13
DOIs
Publication statusPublished - Dec 1 1999

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Keywords

  • 2-acetylaminofluorene
  • Aflatoxin B1
  • Carcinogens
  • Mice
  • Thioacetamide
  • Transforming growth factor beta
  • Transgenic

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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