Chemical and colloidal stability of carboxylated core-shell magnetite nanoparticles designed for biomedical applications

Márta Szekeres, Ildikó Y. Tóth, Erzsébet Illés, Angéla Hajdú, István Zupkó, Katalin Farkas, Gábor Oszlánczi, László Tiszlavicz, Etelka Tombácz

Research output: Contribution to journalArticle

49 Citations (Scopus)


Despite the large efforts to prepare super paramagnetic iron oxide nanoparticles (MNPs) for biomedical applications, the number of FDA or EMA approved formulations is few. It is not known commonly that the approved formulations in many instances have already been withdrawn or discontinued by the producers; at present, hardly any approved formulations are produced and marketed. Literature survey reveals that there is a lack for a commonly accepted physicochemical practice in designing and qualifying formulations before they enter in vitro and in vivo biological testing. Such a standard procedure would exclude inadequate formulations from clinical trials thus improving their outcome. Here we present a straightforward route to assess eligibility of carboxylated MNPs for biomedical tests applied for a series of our core-shell products, i.e., citric acid, gallic acid, poly(acrylic acid) and poly(acrylic acid-co-maleic acid) coated MNPs. The discussion is based on physicochemical studies (carboxylate adsorption/desorption, FTIR-ATR, iron dissolution, zeta potential, particle size, coagulation kinetics and magnetization measurements) and involves in vitro and in vivo tests. Our procedure can serve as an example to construct adequate physico-chemical selection strategies for preparation of other types of core-shell nanoparticles as well.

Original languageEnglish
Pages (from-to)14550-14574
Number of pages25
JournalInternational journal of molecular sciences
Issue number7
Publication statusPublished - Jul 2013


  • Adsorption
  • Biocompatibility
  • Biomedical application
  • Carboxylated magnetite nanoparticles
  • Chemical stability
  • Colloidal stability
  • Core-shell nanoparticles
  • Iron dissolution
  • Particle charge
  • Surface complexation

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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