Chemical and colloidal stability of carboxylated core-shell magnetite nanoparticles designed for biomedical applications

M. Szekeres, Ildikó Y. Tóth, E. Illés, Angéla Hajdú, I. Zupkó, Katalin Farkas, Gábor Oszlánczi, L. Tiszlavicz, E. Tombácz

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Despite the large efforts to prepare super paramagnetic iron oxide nanoparticles (MNPs) for biomedical applications, the number of FDA or EMA approved formulations is few. It is not known commonly that the approved formulations in many instances have already been withdrawn or discontinued by the producers; at present, hardly any approved formulations are produced and marketed. Literature survey reveals that there is a lack for a commonly accepted physicochemical practice in designing and qualifying formulations before they enter in vitro and in vivo biological testing. Such a standard procedure would exclude inadequate formulations from clinical trials thus improving their outcome. Here we present a straightforward route to assess eligibility of carboxylated MNPs for biomedical tests applied for a series of our core-shell products, i.e., citric acid, gallic acid, poly(acrylic acid) and poly(acrylic acid-co-maleic acid) coated MNPs. The discussion is based on physicochemical studies (carboxylate adsorption/desorption, FTIR-ATR, iron dissolution, zeta potential, particle size, coagulation kinetics and magnetization measurements) and involves in vitro and in vivo tests. Our procedure can serve as an example to construct adequate physico-chemical selection strategies for preparation of other types of core-shell nanoparticles as well.

Original languageEnglish
Pages (from-to)14550-14574
Number of pages25
JournalInternational Journal of Molecular Sciences
Volume14
Issue number7
DOIs
Publication statusPublished - Jul 2013

Fingerprint

carbopol 940
Magnetite Nanoparticles
Magnetite nanoparticles
magnetite
Nanoparticles
formulations
nanoparticles
Gallic Acid
Acids
Fourier Transform Infrared Spectroscopy
Zeta potential
Coagulation
Particle Size
Citric Acid
Adsorption
Acrylics
acrylic acid
Desorption
Magnetization
Dissolution

Keywords

  • Adsorption
  • Biocompatibility
  • Biomedical application
  • Carboxylated magnetite nanoparticles
  • Chemical stability
  • Colloidal stability
  • Core-shell nanoparticles
  • Iron dissolution
  • Particle charge
  • Surface complexation

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Chemical and colloidal stability of carboxylated core-shell magnetite nanoparticles designed for biomedical applications. / Szekeres, M.; Tóth, Ildikó Y.; Illés, E.; Hajdú, Angéla; Zupkó, I.; Farkas, Katalin; Oszlánczi, Gábor; Tiszlavicz, L.; Tombácz, E.

In: International Journal of Molecular Sciences, Vol. 14, No. 7, 07.2013, p. 14550-14574.

Research output: Contribution to journalArticle

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