Chemical analysis of the edible mushroom tricholoma populinum: Steroids and sulfinyladenosine compounds

Bernadett Kovács, Zoltán Béni, Miklós Dékány, Orsolya Orbán-Gyapai, Izabella Sinka, I. Zupkó, J. Hohmann, Attila Ványolós

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Ten compounds have been identified in the methanol extract of cottonwood mushroom (Tricholoma populinum J.E. Lange), 9 of them for the first time in this species. Besides adenosine (8) and nicotinamide (7) the isolated compounds were ergostane type steroids (1-6) and rare sulfinyladenosine constituents (9 and 10). The chemical structures of these compounds were elucidated by means of extensive spectroscopic methods (NMR and MS). Compounds 3-6 were evaluated for their potential antiproliferative activity against human cancer cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The xanthine oxidase (XO) inhibitory activity of 7-10 has been examined by spectrophotometric method. Cerevisterol (3), its methylated derivative (5) and 3-glycoside of ergosterol peroxide (6) showed significant antiproliferative activity on human breast cancer cell lines.

Original languageEnglish
Pages (from-to)1583-1584
Number of pages2
JournalNatural Product Communications
Volume12
Issue number10
Publication statusPublished - Jan 1 2017

Fingerprint

Tricholoma
Agaricales
Human Activities
chemical analysis
mushrooms
steroids
Steroids
cell lines
Populus
Cell Line
nicotinamide
xanthine oxidase
Niacinamide
Xanthine Oxidase
ergosterol
adenosine
Glycosides
peroxides
bromides
chemical structure

Keywords

  • Antiproliferative
  • Mushroom
  • Steroids.
  • Sulfinyladenosine
  • Tricholoma populinum

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

Cite this

Kovács, B., Béni, Z., Dékány, M., Orbán-Gyapai, O., Sinka, I., Zupkó, I., ... Ványolós, A. (2017). Chemical analysis of the edible mushroom tricholoma populinum: Steroids and sulfinyladenosine compounds. Natural Product Communications, 12(10), 1583-1584.

Chemical analysis of the edible mushroom tricholoma populinum : Steroids and sulfinyladenosine compounds. / Kovács, Bernadett; Béni, Zoltán; Dékány, Miklós; Orbán-Gyapai, Orsolya; Sinka, Izabella; Zupkó, I.; Hohmann, J.; Ványolós, Attila.

In: Natural Product Communications, Vol. 12, No. 10, 01.01.2017, p. 1583-1584.

Research output: Contribution to journalArticle

Kovács, B, Béni, Z, Dékány, M, Orbán-Gyapai, O, Sinka, I, Zupkó, I, Hohmann, J & Ványolós, A 2017, 'Chemical analysis of the edible mushroom tricholoma populinum: Steroids and sulfinyladenosine compounds', Natural Product Communications, vol. 12, no. 10, pp. 1583-1584.
Kovács B, Béni Z, Dékány M, Orbán-Gyapai O, Sinka I, Zupkó I et al. Chemical analysis of the edible mushroom tricholoma populinum: Steroids and sulfinyladenosine compounds. Natural Product Communications. 2017 Jan 1;12(10):1583-1584.
Kovács, Bernadett ; Béni, Zoltán ; Dékány, Miklós ; Orbán-Gyapai, Orsolya ; Sinka, Izabella ; Zupkó, I. ; Hohmann, J. ; Ványolós, Attila. / Chemical analysis of the edible mushroom tricholoma populinum : Steroids and sulfinyladenosine compounds. In: Natural Product Communications. 2017 ; Vol. 12, No. 10. pp. 1583-1584.
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