Chemical analysis of the edible mushroom tricholoma populinum: Steroids and sulfinyladenosine compounds

Bernadett Kovács, Zoltán Béni, Miklós Dékány, Orsolya Orbán-Gyapai, Izabella Sinka, I. Zupkó, J. Hohmann, Attila Ványolós

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2 Citations (Scopus)

Abstract

Ten compounds have been identified in the methanol extract of cottonwood mushroom (Tricholoma populinum J.E. Lange), 9 of them for the first time in this species. Besides adenosine (8) and nicotinamide (7) the isolated compounds were ergostane type steroids (1-6) and rare sulfinyladenosine constituents (9 and 10). The chemical structures of these compounds were elucidated by means of extensive spectroscopic methods (NMR and MS). Compounds 3-6 were evaluated for their potential antiproliferative activity against human cancer cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The xanthine oxidase (XO) inhibitory activity of 7-10 has been examined by spectrophotometric method. Cerevisterol (3), its methylated derivative (5) and 3-glycoside of ergosterol peroxide (6) showed significant antiproliferative activity on human breast cancer cell lines.

Original languageEnglish
Pages (from-to)1583-1584
Number of pages2
JournalNatural Product Communications
Volume12
Issue number10
Publication statusPublished - Jan 1 2017

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Keywords

  • Antiproliferative
  • Mushroom
  • Steroids.
  • Sulfinyladenosine
  • Tricholoma populinum

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

Cite this

Kovács, B., Béni, Z., Dékány, M., Orbán-Gyapai, O., Sinka, I., Zupkó, I., Hohmann, J., & Ványolós, A. (2017). Chemical analysis of the edible mushroom tricholoma populinum: Steroids and sulfinyladenosine compounds. Natural Product Communications, 12(10), 1583-1584.