Charge-transfer chromatographic study on the inclusion complex formation of some barbituric acid derivatives with varrious cyclodextrins

T. Cserháti, J. Szejtli, J. Bojarski

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The inclusion complexing capacity of 21 barbituric acid derivatives with α-, β- and γ-cyclodextrins, with a water soluble β-cyclodextrin polymer and with 2,6-di-O-methyl-β-cyclodextrin was determined by chargetransfer chromatography on reversed-phase thin-layer plates. It was established that 2,6-di-O-methyl-β-cyclodextrin formed the most stable complexes with the barbituric acid derivatives followed by the water soluble β-cyclodextrin polymer. The complex forming capacities of β- and γ-cyclodextrins were similar to each other while the α-cyclodextrin formed very weak complexes. Each cyclodextrin had a different sterical requirement of substituents of the barbituric acid derivatives to fit optimally into the cyclodextrin cavity.

Original languageEnglish
Pages (from-to)455-458
Number of pages4
JournalChromatographia
Volume28
Issue number9-10
DOIs
Publication statusPublished - Nov 1989

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Cyclodextrins
Charge transfer
Derivatives
Water
Reverse-Phase Chromatography
Chromatography
barbituric acid

Keywords

  • Barbituric acid derivatives
  • Charge-transfer
  • Inclusion complexes of cyclodextrins
  • Thin-layer chromatography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

Cite this

Charge-transfer chromatographic study on the inclusion complex formation of some barbituric acid derivatives with varrious cyclodextrins. / Cserháti, T.; Szejtli, J.; Bojarski, J.

In: Chromatographia, Vol. 28, No. 9-10, 11.1989, p. 455-458.

Research output: Contribution to journalArticle

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