Charge-transfer chromatographic study of the interaction of non-ionic surfactants with hydroxypropyl-β-cyclodextrin

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Abstract

The interaction of 38 ethoxylated and one non-ethoxylated non-ionic surfactants with hydroxypropyl-β-cyclodextrin (HPBCD) was studied by reversed-phase charge-transfer chromatography. The relative strength of interaction, the hydrophobicity and the specific hydrophobic surface area of the surfactants and the effect of methanol concentration on the strength of interaction were calculated. The presence of a phenyl group and the length of the alkyl chain in the hydrophobic moiety of the surfactants have the greatest impact on their hydrophobic character, and the role of the length of the polar ethylene oxide chain is negligible. Surfactants with a tributylphenol hydrophobic moiety did not form complexes with HPBCD, the cavity of HPBCD probably being too small for the insertion of the bulky tributylphenol group. Most surfactants formed complexes with HPBCD, but the strength of interaction varied considerably. Stepwise regression analysis indicated that both the hydrophobicity and the specific hydrophobic surface area of the surfactants significantly influenced the strength of interaction, demonstrating the importance of hydrophobic interactions in inclusion complex formation between non-ionic surfactants and HPBCD.

Original languageEnglish
Pages (from-to)17-25
Number of pages9
JournalJournal of Chromatography A
Volume665
Issue number1
DOIs
Publication statusPublished - Apr 8 1994

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Nonionic surfactants
Cyclodextrins
Surface-Active Agents
Charge transfer
Hydrophobic and Hydrophilic Interactions
Hydrophobicity
Ethylene Oxide
Chromatography
Regression analysis
Methanol
Regression Analysis

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

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title = "Charge-transfer chromatographic study of the interaction of non-ionic surfactants with hydroxypropyl-β-cyclodextrin",
abstract = "The interaction of 38 ethoxylated and one non-ethoxylated non-ionic surfactants with hydroxypropyl-β-cyclodextrin (HPBCD) was studied by reversed-phase charge-transfer chromatography. The relative strength of interaction, the hydrophobicity and the specific hydrophobic surface area of the surfactants and the effect of methanol concentration on the strength of interaction were calculated. The presence of a phenyl group and the length of the alkyl chain in the hydrophobic moiety of the surfactants have the greatest impact on their hydrophobic character, and the role of the length of the polar ethylene oxide chain is negligible. Surfactants with a tributylphenol hydrophobic moiety did not form complexes with HPBCD, the cavity of HPBCD probably being too small for the insertion of the bulky tributylphenol group. Most surfactants formed complexes with HPBCD, but the strength of interaction varied considerably. Stepwise regression analysis indicated that both the hydrophobicity and the specific hydrophobic surface area of the surfactants significantly influenced the strength of interaction, demonstrating the importance of hydrophobic interactions in inclusion complex formation between non-ionic surfactants and HPBCD.",
author = "T. Cserh{\'a}ti and E. Forg{\'a}cs",
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T1 - Charge-transfer chromatographic study of the interaction of non-ionic surfactants with hydroxypropyl-β-cyclodextrin

AU - Cserháti, T.

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N2 - The interaction of 38 ethoxylated and one non-ethoxylated non-ionic surfactants with hydroxypropyl-β-cyclodextrin (HPBCD) was studied by reversed-phase charge-transfer chromatography. The relative strength of interaction, the hydrophobicity and the specific hydrophobic surface area of the surfactants and the effect of methanol concentration on the strength of interaction were calculated. The presence of a phenyl group and the length of the alkyl chain in the hydrophobic moiety of the surfactants have the greatest impact on their hydrophobic character, and the role of the length of the polar ethylene oxide chain is negligible. Surfactants with a tributylphenol hydrophobic moiety did not form complexes with HPBCD, the cavity of HPBCD probably being too small for the insertion of the bulky tributylphenol group. Most surfactants formed complexes with HPBCD, but the strength of interaction varied considerably. Stepwise regression analysis indicated that both the hydrophobicity and the specific hydrophobic surface area of the surfactants significantly influenced the strength of interaction, demonstrating the importance of hydrophobic interactions in inclusion complex formation between non-ionic surfactants and HPBCD.

AB - The interaction of 38 ethoxylated and one non-ethoxylated non-ionic surfactants with hydroxypropyl-β-cyclodextrin (HPBCD) was studied by reversed-phase charge-transfer chromatography. The relative strength of interaction, the hydrophobicity and the specific hydrophobic surface area of the surfactants and the effect of methanol concentration on the strength of interaction were calculated. The presence of a phenyl group and the length of the alkyl chain in the hydrophobic moiety of the surfactants have the greatest impact on their hydrophobic character, and the role of the length of the polar ethylene oxide chain is negligible. Surfactants with a tributylphenol hydrophobic moiety did not form complexes with HPBCD, the cavity of HPBCD probably being too small for the insertion of the bulky tributylphenol group. Most surfactants formed complexes with HPBCD, but the strength of interaction varied considerably. Stepwise regression analysis indicated that both the hydrophobicity and the specific hydrophobic surface area of the surfactants significantly influenced the strength of interaction, demonstrating the importance of hydrophobic interactions in inclusion complex formation between non-ionic surfactants and HPBCD.

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