Charge-transfer chromatographic study of the interaction of anticancer drugs with acetyl-β-cyclodextrin

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Abstract

The interaction between 23 anticancer drugs and acetyl-β-cyclodextrin (acetyl-β-CD) was studied by reversed-phase charge-transfer thin-layer chromatography and the relative strength of interaction was calculated. Acetyl-β-CD formed inclusion complexes with 16 compounds, the complex always being more hydrophilic than the uncomplexed drug. The inclusion forming capacity of drugs differed considerably according to their chemical structure. The significant linear correlation between the hydrophobicity and specific hydrophobic surface area of anticancer drugs indicated that they can be considered as a homologous series of compounds, however, their chemical structures are highly different.

Original languageEnglish
Pages (from-to)751-755
Number of pages5
JournalFresenius' Journal of Analytical Chemistry
Volume349
Issue number10-11
DOIs
Publication statusPublished - Oct 1 1994

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ASJC Scopus subject areas

  • Biochemistry

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