Charge-transfer chromatographic study of the interaction of antibiotics with sodium dodecylsulfate

Esther Forgács, Tibor Csethati

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The interaction of 29 antibiotics with the anionic surfactant sodium dodecylsulfate (SDS) was studied by charge-transfer reversed-phase chromatography carried out on impregnated silica layers using water-methanol mixtures as eluents. The hydrophobicity of antibiotics and the relative strength of SDS-antibiotic interaction was calculated separately for each antibiotic-SDS pair. SDS interacted with 17 antibiotics where the antibiotic-SDS complex was either more hydrophillic or more hydrophobic than the uncomplexed molecule. The relative strength of interaction depended considerably on the molecular structure of the antibiotics. No significant linear correlation was found between the hydrophobicity parameters of antibiotics and their capacity to interact with SDS. Stepwise regression analysis proved that the inductive effect of substituents, their electron-withdrawing power and proton-acceptor capacity exert a significance influence on the strength of interaction.

Original languageEnglish
Pages (from-to)1295-1302
Number of pages8
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume15
Issue number9-10
DOIs
Publication statusPublished - Jun 1997

Fingerprint

Charge transfer
Sodium
Anti-Bacterial Agents
Hydrophobicity
Hydrophobic and Hydrophilic Interactions
Anionic surfactants
Reverse-Phase Chromatography
Chromatography
Molecular Structure
Surface-Active Agents
Regression analysis
Silicon Dioxide
Molecular structure
Methanol
Protons
Regression Analysis
Electrons
Molecules
Water

Keywords

  • Antibiotics
  • Charge-transfer chromatography
  • Sodium dodecylsulfate

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science

Cite this

Charge-transfer chromatographic study of the interaction of antibiotics with sodium dodecylsulfate. / Forgács, Esther; Csethati, Tibor.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 15, No. 9-10, 06.1997, p. 1295-1302.

Research output: Contribution to journalArticle

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