Charge-transfer chromatographic study of the complex formation of some anticancer drugs with γ-cyclodextrin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The interaction between 23 anticancer drugs and γ-cyclodextrin (γ-CD) was studied by reversed-phase charge-transfer thin-layer chromatography and the relative strength of interaction was calculated. γ-CD formed inclusion complexes with 14 compounds, the complex always being more or less hydrophobic than the uncomplexed drug. The inclusion-forming capacity of a drug differed considerably depending on its chemical structure. The linear correlation between the hydrophobicity and the specific hydrophobic surface area of anticancer drugs indicated that they can be considered a homologous series of compounds, although their chemical structures are highly different.

Original languageEnglish
Pages (from-to)328-332
Number of pages5
JournalAnalytical Biochemistry
Volume225
Issue number2
DOIs
Publication statusPublished - Mar 1995

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Charge-transfer chromatographic study of the complex formation of some anticancer drugs with γ-cyclodextrin'. Together they form a unique fingerprint.

  • Cite this