Charge-Transfer Chromatographic Study of the Complex Formation of Some Anticancer Drugs with γ-Cyclodextrin

Research output: Contribution to journalArticle

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Abstract

The interaction between 23 anticancer drugs and γ-cyclodextrin (γ-CD) was studied by reversed-phase charge-transfer thin-layer chromatography and the relative strength of interaction was calculated. γ-CD formed inclusion complexes with 14 compounds, the complex always being more or less hydrophobic than the uncomplexed drug. The inclusion-forming capacity of a drug differed considerably depending on its chemical structure. The linear correlation between the hydrophobicity and the specific hydrophobic surface area of anticancer drugs indicated that they can be considered a homologous series of compounds, although their chemical structures are highly different.

Original languageEnglish
Pages (from-to)328-332
Number of pages5
JournalAnalytical Biochemistry
Volume225
Issue number2
DOIs
Publication statusPublished - Mar 1995

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Cyclodextrins
Charge transfer
Pharmaceutical Preparations
Thin layer chromatography
Hydrophobicity
Thin Layer Chromatography
Hydrophobic and Hydrophilic Interactions

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Biophysics
  • Biochemistry

Cite this

Charge-Transfer Chromatographic Study of the Complex Formation of Some Anticancer Drugs with γ-Cyclodextrin. / Cserhati, T.

In: Analytical Biochemistry, Vol. 225, No. 2, 03.1995, p. 328-332.

Research output: Contribution to journalArticle

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