Characterization of two distinct DP-related genes from Arabidopsis thaliana

Zoltán Magyar, Ana Atanassova, Lieven De Veylder, Stéphane Rombauts, Dirk Inzé

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61 Citations (Scopus)

Abstract

E2F/DP complexes play a pivotal role in the regulation of the G1/S transition in animals. Recently, plant E2F homologs have been cloned, but DP-related sequences have not been identified so far. Here we report that Arabidopsis thaliana contains at least two different DP-related genes, AtDPa and AtDPb. They exhibit an overall domain organization similar to that of their animal counterparts, although phylogenetic analysis demonstrated that they form a separate subgroup. AtDPs efficiently heterodimerize in vitro with the Arabidopsis E2F-related proteins, AtE2Fa and AtE2Fb through their dimerization domains. AtDPa and AtE2Fa are predominantly produced in actively dividing cells with highest transcript levels in early S phase cells. (C) 2000 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)79-87
Number of pages9
JournalFEBS letters
Volume486
Issue number1
DOIs
Publication statusPublished - Dec 1 2000

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Keywords

  • Arabidopsis thaliana
  • DP
  • E2F
  • G1/S transition

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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