Characterization of two different toxins of Wickerhamomyces anomalus (pichia anomala) VKM Y-159

Z. Farkas, J. Márki-Zay, Judit Kucsera, Cs Vágvölgyi, W. I. Golubev, Ilona Pfeiffer

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Abstract

Wickerhamomyces anomalus VKM Y-159 strain produces two types of toxin designated as WAKT a and WAKT b, encoded by chromosomal genes. The WAKT a toxin is heat-labile, pronase sensitive acting in pH range 3-4 affecting on several yeasts including pathogenic Candida species while the WAKT b toxin is protease- and thermo-resistant, acting in pH range 3-7 on two species, Candida alai and Candida norvegica. The rapid decrease of the number of viable cells after toxin treatment demonstrates that both toxins have cytocidic effect.

Original languageEnglish
Pages (from-to)277-287
Number of pages11
JournalActa biologica Hungarica
Volume63
Issue number2
DOIs
Publication statusPublished - May 1 2012

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Keywords

  • Wickerhamomyces anomalus
  • killer toxins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

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