Characterization of the iron core in Ferrifol ® , a pharmaceutical analogue of ferritin, using Mössbauer spectroscopy and magnetization measurements

I. V. Alenkina, I. Felner, E. Kuzmann, M. I. Oshtrakh

Research output: Contribution to journalArticle

Abstract

Mössbauer spectra of Ferrifol ® measured at 295, 220, 140 and 90 K demonstrated non-Lorentzian two-peak spectra which were better fitted using a superposition of 5 quadrupole doublets with different quadrupole splitting but similar isomer shift and equal line width. Unusual line broadening was observed in the Mössbauer spectra of Ferrifol ® measured in this temperature range. This is consistent with the unusual line broadening already observed earlier in the Mössbauer spectra (295–90 K) of ferritin and its pharmaceutical analogues Ferrum Lek and Maltofer ® (Oshtrakh M.I. et al., Spectrochim. Acta, Part A: Mol. Biomol. Spectrosc., 2017, 172, 14–24, DOI: 10.1016/j.saa.2016.06.034). The Mössbauer spectrum of Ferrifol ® at 60 K demonstrated a slow decrease of magnetic relaxation in the iron core. Magnetization measurements revealed mainly paramagnetic state of the Ferrifol ® iron core and apparently blocking temperature around 33 K.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalJournal of Molecular Structure
Volume1183
DOIs
Publication statusPublished - May 5 2019

Fingerprint

Ferritins
Magnetization
Iron
Spectroscopy
Magnetic relaxation
Isomers
Pharmaceutical Preparations
Linewidth
Temperature
ferrum lek

Keywords

  • Ferrifol
  • Iron core
  • Magnetization measurements
  • Mössbauer spectroscopy

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Characterization of the iron core in Ferrifol ® , a pharmaceutical analogue of ferritin, using Mössbauer spectroscopy and magnetization measurements . / Alenkina, I. V.; Felner, I.; Kuzmann, E.; Oshtrakh, M. I.

In: Journal of Molecular Structure, Vol. 1183, 05.05.2019, p. 281-286.

Research output: Contribution to journalArticle

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abstract = "M{\"o}ssbauer spectra of Ferrifol {\circledR} measured at 295, 220, 140 and 90 K demonstrated non-Lorentzian two-peak spectra which were better fitted using a superposition of 5 quadrupole doublets with different quadrupole splitting but similar isomer shift and equal line width. Unusual line broadening was observed in the M{\"o}ssbauer spectra of Ferrifol {\circledR} measured in this temperature range. This is consistent with the unusual line broadening already observed earlier in the M{\"o}ssbauer spectra (295–90 K) of ferritin and its pharmaceutical analogues Ferrum Lek and Maltofer {\circledR} (Oshtrakh M.I. et al., Spectrochim. Acta, Part A: Mol. Biomol. Spectrosc., 2017, 172, 14–24, DOI: 10.1016/j.saa.2016.06.034). The M{\"o}ssbauer spectrum of Ferrifol {\circledR} at 60 K demonstrated a slow decrease of magnetic relaxation in the iron core. Magnetization measurements revealed mainly paramagnetic state of the Ferrifol {\circledR} iron core and apparently blocking temperature around 33 K.",
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AU - Oshtrakh, M. I.

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