Characterization of penicillin-, aminoglycoside- and lincosamide-inactivating enzymes determined by Staphylococcus epidermidis plasmid PBI109PGL

I. Barcs, J. Pászti

Research output: Contribution to journalArticle

Abstract

In staphylococci, resistance to antibacterial agents is generally due to resistance plasmids (R plasmids). These are found in a wide variety of staphylococcal species, and encode for resistance to penicillins, chloramphenicol, tetracycline, macrolides, lincosamides and aminoglycosides. There are four classic resistance mechanisms that are specified by plasmids: altered target size impermeability, bypass and enzymatic inactivation of the drug molecule. A more recently identified mechanism is active efflux. In this report, we characterize a new 44 kb plasmid of Staphylococcus epidermidis which confers resistance by enzymatic inactivation to three different antibiotic groups: penicillins, aminoglycosides and lincosamides. Penicillin resistance derives from production of an inducible type-V β-lactamase, aminoglycoside resistance is due to an aminoglycoside 6' acetyltransferase V and resistance to lincosamides comes from a lincosamide inactivation nucleotydilation enzyme A'.

Original languageEnglish
Pages (from-to)103-111
Number of pages9
JournalAlpe Adria Microbiology Journal
Volume3
Issue number2
Publication statusPublished - 1994

Fingerprint

Lincosamides
Staphylococcus epidermidis
Aminoglycosides
Penicillins
Plasmids
Penicillin Resistance
Enzymes
Macrolides
Chloramphenicol
Tetracycline
Staphylococcus
Anti-Bacterial Agents
Pharmaceutical Preparations

Keywords

  • β-lactamase
  • aminoglycoside
  • enzymat ic inactivation
  • lincosamide
  • plasmid
  • Staphylococcus

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

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abstract = "In staphylococci, resistance to antibacterial agents is generally due to resistance plasmids (R plasmids). These are found in a wide variety of staphylococcal species, and encode for resistance to penicillins, chloramphenicol, tetracycline, macrolides, lincosamides and aminoglycosides. There are four classic resistance mechanisms that are specified by plasmids: altered target size impermeability, bypass and enzymatic inactivation of the drug molecule. A more recently identified mechanism is active efflux. In this report, we characterize a new 44 kb plasmid of Staphylococcus epidermidis which confers resistance by enzymatic inactivation to three different antibiotic groups: penicillins, aminoglycosides and lincosamides. Penicillin resistance derives from production of an inducible type-V β-lactamase, aminoglycoside resistance is due to an aminoglycoside 6' acetyltransferase V and resistance to lincosamides comes from a lincosamide inactivation nucleotydilation enzyme A'.",
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author = "I. Barcs and J. P{\'a}szti",
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N2 - In staphylococci, resistance to antibacterial agents is generally due to resistance plasmids (R plasmids). These are found in a wide variety of staphylococcal species, and encode for resistance to penicillins, chloramphenicol, tetracycline, macrolides, lincosamides and aminoglycosides. There are four classic resistance mechanisms that are specified by plasmids: altered target size impermeability, bypass and enzymatic inactivation of the drug molecule. A more recently identified mechanism is active efflux. In this report, we characterize a new 44 kb plasmid of Staphylococcus epidermidis which confers resistance by enzymatic inactivation to three different antibiotic groups: penicillins, aminoglycosides and lincosamides. Penicillin resistance derives from production of an inducible type-V β-lactamase, aminoglycoside resistance is due to an aminoglycoside 6' acetyltransferase V and resistance to lincosamides comes from a lincosamide inactivation nucleotydilation enzyme A'.

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