Characterization of neurons containing nerve growth factor receptors in the rat neostriatum

Jozsef Kiss, Ambrish J. Patel

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Abstract

Using a sensitive immunohistochemical procedure, the normal morphology and distribution of neurons containing the nerve growth factor receptors (NGF-R) have been studied in the caudate-putamen of the adult rat brain, and the findings compared with observations on the choline acetyltransferase (ChAT)-positive neurons present in the immediately adjacent sections. The ChAT immunoreaction product was uniformly distributed on the cell bodies, while the NGF-R immunoreaction end product was present also as intensely stained granules (0.06-0.12 μm diameter) on the cell somata and the dendrites. In the NGF-R-positive neurons the intensity of the reaction product was much weaker than the ChAT immunoreactivity. Moreover, in comparison with ChAT-immunopositive cells, the proportion of the NGF-R-immunoreactive neurons was on average about 15% in the neostriatum.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalNeuroscience Letters
Volume105
Issue number3
DOIs
Publication statusPublished - Nov 6 1989

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Keywords

  • Choline acetyltransferase
  • Immunohistochemistry
  • Neostriatum
  • Nerve growth factor receptor
  • Rat caudate-putamen

ASJC Scopus subject areas

  • Neuroscience(all)

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