Characterization of neocortical principal cells and interneurons by network interactions and extracellular features

P. Barthó, Hajime Hirase, Lenaïc Monconduit, Michael Zugaro, Kenneth D. Harris, György Buzsáki

Research output: Contribution to journalArticle

392 Citations (Scopus)

Abstract

Most neuronal interactions in the cortex occur within local circuits. Because principal cells and GABAergic interneurons contribute differently to cortical operations, their experimental identification and separation is of utmost important. We used 64-site two-dimensional silicon probes for high-density recording of local neurons in layer 5 of the somatosensory and prefrontal cortices of the rat. Multiple-site monitoring of units allowed for the determination of their two-dimensional spatial position in the brain. Of the ∼60,000 cell pairs recorded, 0.2% showed robust short-term interactions. Units with significant, short-latency (

Original languageEnglish
Pages (from-to)600-608
Number of pages9
JournalJournal of Neurophysiology
Volume92
Issue number1
DOIs
Publication statusPublished - Jul 2004

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Interneurons
Somatosensory Cortex
Silicon
Prefrontal Cortex
Neurons
Brain

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

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Characterization of neocortical principal cells and interneurons by network interactions and extracellular features. / Barthó, P.; Hirase, Hajime; Monconduit, Lenaïc; Zugaro, Michael; Harris, Kenneth D.; Buzsáki, György.

In: Journal of Neurophysiology, Vol. 92, No. 1, 07.2004, p. 600-608.

Research output: Contribution to journalArticle

Barthó, P. ; Hirase, Hajime ; Monconduit, Lenaïc ; Zugaro, Michael ; Harris, Kenneth D. ; Buzsáki, György. / Characterization of neocortical principal cells and interneurons by network interactions and extracellular features. In: Journal of Neurophysiology. 2004 ; Vol. 92, No. 1. pp. 600-608.
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