Gége-és hypopharyngealis rákok jellemzése. Tumorméret és vaszkularizáció

Translated title of the contribution: Characterization of laryngopharyngeal tumors. Tumor size and vascularization

Research output: Contribution to journalArticle

Abstract

A recent survey of head and neck cancer indicated a sharp difference in survival between cancer of the hypopharyx and cancers formed in other head and neck sites. We have analyzed tumor size relative to clinical stage and vascularization as possible causes for such a difference in a series of 21 patients with cancers of the laryngopharynx (11 glottic and 10 hypopharyngeal). We found that the volume of the smallest cancers of the larynx at stage 2 are significantly larger than the volume of the cancers of the hypopharynx at stage 4 (p<0.05). Next, we have determined by immunohistochemistry and morphometry the microvessel density (MVD), microvessel perimeter (MVP) and VEGF expression of laryngo-hypopharyngeal cancers. Analysis of these data indicates that there is no difference in vascularization and VEGF expression between these two tumor types. These data strongly suggest that the invasive- but not the angiogenic phenotype of hypopharyngeal cancer cells could be responsible for the more aggressive biological behavior of this head and neck cancer subtype.

Translated title of the contributionCharacterization of laryngopharyngeal tumors. Tumor size and vascularization
Original languageHungarian
Pages (from-to)239-245
Number of pages7
JournalMagyar onkologia
Volume44
Issue number3
Publication statusPublished - Dec 1 2000

ASJC Scopus subject areas

  • Medicine(all)

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