Characterization of inflammatory cell infiltrate in dental periapical lesions.

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Abstract

Sixty-three dental periapical lesions were investigated in order to study the involvement of inflammatory and immunologic reactions in the pathogenesis and maintenance of chronic apical periodontitis. Of 61 well-preserved specimens, 38 were classified as granulomatous, 3 as exudative periapical granulomas and 20 as periapical scars. The quantitative composition of T-lymphocyte subpopulation and macrophages, the proportion of IgE-producing cells compared with other immunoglobulin producing plasma cells, and the tissue distribution of IgE-producing plasma cells compared with that of mast cells were determined in the granulomatous types of granulomas using immunofluorescent, immunohistochemical and enzymehistochemical methods. The results indicated a decreased ratio of helper/inducer versus cytotoxic/suppressor T-lymphocytes, a remarkably high proportion of macrophages, a low frequency of IgE-producing plasma cells with different localization when compared with that of mast cells. These observations suggest that T-lymphocytes and macrophages may play an important role in the complex events of tissue destruction and repair taking place in the periapical region.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalInternational Endodontic Journal
Volume26
Issue number2
Publication statusPublished - Mar 1993

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Plasma Cells
Immunoglobulin E
Tooth
Macrophages
Mast Cells
Periapical Granuloma
Periapical Periodontitis
T-Lymphocytes
Antibody-Producing Cells
Chronic Periodontitis
Lymphocyte Subsets
Cytotoxic T-Lymphocytes
Tissue Distribution
Granuloma
Cicatrix
Maintenance

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Characterization of inflammatory cell infiltrate in dental periapical lesions. / Márton, I.; Kiss, C.

In: International Endodontic Journal, Vol. 26, No. 2, 03.1993, p. 131-136.

Research output: Contribution to journalArticle

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