Characterization of ethylcellulose free films by positron annihilation spectroscopy and mechanical testing

Diána Hegyesi, K. Süvegh, András Kelemen, K. Pintye-Hódi, Géza Regdon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The distribution of the plasticizer triethyl citrate between the chains of the polymer ethylcellulose was determined in order to explain the mechanical properties. A knowledge of these properties is indispensable for preformulation studies. As preformulation, the relationship between the mechanical properties and the distribution of the plasticizer was studied. The distribution was investigated with positron annihilation lifetime spectroscopy, and the mechanical properties with breaking hardness tests. Two kinds of ethylcellulose were used. The best film-former with plasticizer was chosen with the optimal concentration. Selection of the optimum type and concentration of the plasticizer is essential in the formulation of pellets and coated dosage forms.

Original languageEnglish
Pages (from-to)47-50
Number of pages4
JournalMicrochemical Journal
Volume115
DOIs
Publication statusPublished - Jul 2014

Fingerprint

Positron annihilation spectroscopy
Plasticizers
Mechanical testing
Mechanical properties
Positron annihilation
Dosage Forms
Polymers
Hardness
Spectroscopy
ethyl cellulose

Keywords

  • Ethylcellulose
  • Free films
  • Mechanical test
  • PALS
  • Triethyl citrate

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Cite this

Characterization of ethylcellulose free films by positron annihilation spectroscopy and mechanical testing. / Hegyesi, Diána; Süvegh, K.; Kelemen, András; Pintye-Hódi, K.; Regdon, Géza.

In: Microchemical Journal, Vol. 115, 07.2014, p. 47-50.

Research output: Contribution to journalArticle

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