Characterization of diarylheptanoids: An emerging class of bioactive natural products

Ágnes Alberti, Eszter Riethmüller, S. Béni

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Diarylheptanoids are a class of secondary plant metabolites with a wide variety of bioactivity. Research on their phytochemistry and phytoanalysis is rapidly growing and the number of identified structures bearing the aryl-C7-aryl skeleton is at present approaching 500. Historically, the yellow pigment curcumin has been characterized as the first diarylheptanoid and the extensive research on naturally occurring analogues is still ongoing. In this review, studies dealing with the characterization of linear and cyclic derivatives are discussed from the phytoanalytical point of view. Isolation, fractionation and purification strategies from natural sources along with their chromatographic behavior and structural characteristics are discussed. The role of various techniques used for the extraction (such as Soxhlet extraction, sonication, maceration/percolation, microwave-assisted extraction, supercritical carbon dioxide extraction); isolation (liquid–liquid extraction, column chromatographic techniques, preparative thin-layer and high-performance liquid chromatography, centrifugal partition chromatography, counter-current chromatography); separation (thin-layer chromatography, high-performance liquid chromatography, gas chromatography, capillary electrophoresis) and structural characterization (UV/Vis spectroscopy, infrared spectroscopy, X-ray crystallography, mass spectrometry, nuclear magnetic resonance spectroscopy and circular dichroism spectroscopy) are critically reviewed.

Original languageEnglish
Pages (from-to)13-34
Number of pages22
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume147
DOIs
Publication statusPublished - Jan 5 2018

Fingerprint

Diarylheptanoids
Biological Products
Spectrum Analysis
Chromatography
High Pressure Liquid Chromatography
High performance liquid chromatography
Sonication
Curcumin
X Ray Crystallography
Capillary Electrophoresis
Thin Layer Chromatography
Microwaves
Circular Dichroism
Research
Skeleton
Carbon Dioxide
Bearings (structural)
Gas Chromatography
Mass Spectrometry
Circular dichroism spectroscopy

Keywords

  • Curcumin
  • Isolation
  • LC–MS
  • NMR
  • Phytochemical analysis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

Cite this

Characterization of diarylheptanoids : An emerging class of bioactive natural products. / Alberti, Ágnes; Riethmüller, Eszter; Béni, S.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 147, 05.01.2018, p. 13-34.

Research output: Contribution to journalReview article

@article{a98aaf895e4e4d57b2e815793c7ff734,
title = "Characterization of diarylheptanoids: An emerging class of bioactive natural products",
abstract = "Diarylheptanoids are a class of secondary plant metabolites with a wide variety of bioactivity. Research on their phytochemistry and phytoanalysis is rapidly growing and the number of identified structures bearing the aryl-C7-aryl skeleton is at present approaching 500. Historically, the yellow pigment curcumin has been characterized as the first diarylheptanoid and the extensive research on naturally occurring analogues is still ongoing. In this review, studies dealing with the characterization of linear and cyclic derivatives are discussed from the phytoanalytical point of view. Isolation, fractionation and purification strategies from natural sources along with their chromatographic behavior and structural characteristics are discussed. The role of various techniques used for the extraction (such as Soxhlet extraction, sonication, maceration/percolation, microwave-assisted extraction, supercritical carbon dioxide extraction); isolation (liquid–liquid extraction, column chromatographic techniques, preparative thin-layer and high-performance liquid chromatography, centrifugal partition chromatography, counter-current chromatography); separation (thin-layer chromatography, high-performance liquid chromatography, gas chromatography, capillary electrophoresis) and structural characterization (UV/Vis spectroscopy, infrared spectroscopy, X-ray crystallography, mass spectrometry, nuclear magnetic resonance spectroscopy and circular dichroism spectroscopy) are critically reviewed.",
keywords = "Curcumin, Isolation, LC–MS, NMR, Phytochemical analysis",
author = "{\'A}gnes Alberti and Eszter Riethm{\"u}ller and S. B{\'e}ni",
year = "2018",
month = "1",
day = "5",
doi = "10.1016/j.jpba.2017.08.051",
language = "English",
volume = "147",
pages = "13--34",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
issn = "0731-7085",
publisher = "Elsevier",

}

TY - JOUR

T1 - Characterization of diarylheptanoids

T2 - An emerging class of bioactive natural products

AU - Alberti, Ágnes

AU - Riethmüller, Eszter

AU - Béni, S.

PY - 2018/1/5

Y1 - 2018/1/5

N2 - Diarylheptanoids are a class of secondary plant metabolites with a wide variety of bioactivity. Research on their phytochemistry and phytoanalysis is rapidly growing and the number of identified structures bearing the aryl-C7-aryl skeleton is at present approaching 500. Historically, the yellow pigment curcumin has been characterized as the first diarylheptanoid and the extensive research on naturally occurring analogues is still ongoing. In this review, studies dealing with the characterization of linear and cyclic derivatives are discussed from the phytoanalytical point of view. Isolation, fractionation and purification strategies from natural sources along with their chromatographic behavior and structural characteristics are discussed. The role of various techniques used for the extraction (such as Soxhlet extraction, sonication, maceration/percolation, microwave-assisted extraction, supercritical carbon dioxide extraction); isolation (liquid–liquid extraction, column chromatographic techniques, preparative thin-layer and high-performance liquid chromatography, centrifugal partition chromatography, counter-current chromatography); separation (thin-layer chromatography, high-performance liquid chromatography, gas chromatography, capillary electrophoresis) and structural characterization (UV/Vis spectroscopy, infrared spectroscopy, X-ray crystallography, mass spectrometry, nuclear magnetic resonance spectroscopy and circular dichroism spectroscopy) are critically reviewed.

AB - Diarylheptanoids are a class of secondary plant metabolites with a wide variety of bioactivity. Research on their phytochemistry and phytoanalysis is rapidly growing and the number of identified structures bearing the aryl-C7-aryl skeleton is at present approaching 500. Historically, the yellow pigment curcumin has been characterized as the first diarylheptanoid and the extensive research on naturally occurring analogues is still ongoing. In this review, studies dealing with the characterization of linear and cyclic derivatives are discussed from the phytoanalytical point of view. Isolation, fractionation and purification strategies from natural sources along with their chromatographic behavior and structural characteristics are discussed. The role of various techniques used for the extraction (such as Soxhlet extraction, sonication, maceration/percolation, microwave-assisted extraction, supercritical carbon dioxide extraction); isolation (liquid–liquid extraction, column chromatographic techniques, preparative thin-layer and high-performance liquid chromatography, centrifugal partition chromatography, counter-current chromatography); separation (thin-layer chromatography, high-performance liquid chromatography, gas chromatography, capillary electrophoresis) and structural characterization (UV/Vis spectroscopy, infrared spectroscopy, X-ray crystallography, mass spectrometry, nuclear magnetic resonance spectroscopy and circular dichroism spectroscopy) are critically reviewed.

KW - Curcumin

KW - Isolation

KW - LC–MS

KW - NMR

KW - Phytochemical analysis

UR - http://www.scopus.com/inward/record.url?scp=85029874997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029874997&partnerID=8YFLogxK

U2 - 10.1016/j.jpba.2017.08.051

DO - 10.1016/j.jpba.2017.08.051

M3 - Review article

C2 - 28958734

AN - SCOPUS:85029874997

VL - 147

SP - 13

EP - 34

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

SN - 0731-7085

ER -