Characterization of connexin36 gap junctions in the human outer retina

O. Kántor, Zsigmond Benkő, Anna Énzsöly, Csaba Dávid, Angela Naumann, Roland Nitschke, Arnold Szabó, Emese Pálfi, József Orbán, M. Nyitrai, J. Németh, A. Szél, Ákos Lukáts, B. Völgyi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Retinal connexins (Cx) form gap junctions (GJ) in key circuits that transmit average or synchronize signals. Expression of Cx36, -45, -50 and -57 have been described in many species but there is still a disconcerting paucity of information regarding the Cx makeup of human retinal GJs. We used well-preserved human postmortem samples to characterize Cx36 GJ constituent circuits of the outer plexiform layer (OPL). Based on their location, morphometric characteristics and co-localizations with outer retinal neuronal markers, we distinguished four populations of Cx36 plaques in the human OPL. Three of these were comprised of loosely scattered Cx36 plaques; the distalmost population 1 formed cone-to-rod GJs, population 2 in the mid-OPL formed cone-to-cone GJs, whereas the proximalmost population 4 likely connected bipolar cell dendrites. The fourth population (population 3) of Cx36 plaques conglomerated beneath cone pedicles and connected dendritic tips of bipolar cells that shared a common presynaptic cone. Overall, we show that the human outer retina displays a diverse cohort of Cx36 GJ that follows the general mammalian scheme and display a great functional diversity.

Original languageEnglish
Pages (from-to)2963-2984
Number of pages22
JournalBrain Structure and Function
Volume221
Issue number6
DOIs
Publication statusPublished - Jul 1 2016

Fingerprint

Gap Junctions
Retina
Population
Connexins
Vertebrate Photoreceptor Cells
Dendrites
connexin 36

Keywords

  • Bipolar cell
  • Cone
  • Electrical synapse
  • Gap junction
  • Photoreceptor
  • Rod

ASJC Scopus subject areas

  • Neuroscience(all)
  • Anatomy
  • Histology

Cite this

Characterization of connexin36 gap junctions in the human outer retina. / Kántor, O.; Benkő, Zsigmond; Énzsöly, Anna; Dávid, Csaba; Naumann, Angela; Nitschke, Roland; Szabó, Arnold; Pálfi, Emese; Orbán, József; Nyitrai, M.; Németh, J.; Szél, A.; Lukáts, Ákos; Völgyi, B.

In: Brain Structure and Function, Vol. 221, No. 6, 01.07.2016, p. 2963-2984.

Research output: Contribution to journalArticle

Kántor, O, Benkő, Z, Énzsöly, A, Dávid, C, Naumann, A, Nitschke, R, Szabó, A, Pálfi, E, Orbán, J, Nyitrai, M, Németh, J, Szél, A, Lukáts, Á & Völgyi, B 2016, 'Characterization of connexin36 gap junctions in the human outer retina', Brain Structure and Function, vol. 221, no. 6, pp. 2963-2984. https://doi.org/10.1007/s00429-015-1082-z
Kántor, O. ; Benkő, Zsigmond ; Énzsöly, Anna ; Dávid, Csaba ; Naumann, Angela ; Nitschke, Roland ; Szabó, Arnold ; Pálfi, Emese ; Orbán, József ; Nyitrai, M. ; Németh, J. ; Szél, A. ; Lukáts, Ákos ; Völgyi, B. / Characterization of connexin36 gap junctions in the human outer retina. In: Brain Structure and Function. 2016 ; Vol. 221, No. 6. pp. 2963-2984.
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