Characterization of B cell lymphoma in patients with Sjögren's syndrome and hepatitis C virus infection

Manuel Ramos-Casals, Luca L.A. La Civita, Salvatore De Vita, Roser Solans, Mario Luppi, Francisco Medina, Paola Caramaschi, Patrizia Fadda, Ginevra De Marchi, Armando Lopez-Guillermo, Josep Font, Pilar Brito-Zerón, Veronique Loustaud-Ratti, Margit Zeher, Peter Szodoray, Jose Angel Bosch, Albert Selva-O'Callaghan, Miquel Vilardell, Eric Toussirot, Daniel WendlingJose Rosas, Juan Manuel Anaya, Xavier Forns, Jose Sanchez-Tapias, Luis Javier Jara

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Abstract

Objective. To characterize the clinical and immunologic patterns of expression, response to therapy, and outcome of patients with Sjögren's syndrome (SS) and associated hepatitis C virus (HCV) infection who developed B cell lymphoma. Methods. Various international reference centers constituted a multicenter study group with the purpose of creating a registry of patients with SS-HCV who developed B cell lymphoma. A protocol form was used to record the main characteristics of SS, chronic HCV infection, and B cell lymphoma. Results. Twenty-five patients with SS-HCV with B cell lymphoma were included in the registry. There were 22 (88%) women and 3 (12%) men (mean age 55, 58, and 61 years at SS, HCV infection, and lymphoma diagnosis, respectively). The main extraglandular SS manifestations were cutaneous vasculitis in 15 (60%) patients and peripheral neuropathy in 12 (48%); the main immunologic features were positive rheumatoid factor (RF) in 24 (96%) and type II cryoglobulins in 20 (80%). The main histologic subtypes were mucosa-associated lymphoid tissue (MALT) lymphoma in 11 (44%) patients, diffuse large B cell lymphoma in 6 (24%), and follicular center cell lymphoma in 6 (24%). Fifteen (60%) patients had an extranodal primary location, most frequently in the parotid gland (5 patients), liver (4 patients), and stomach (4 patients). Twelve (52%) of 23 patients died after a median followup from the time of lymphoma diagnosis of 4 years, with lymphoma progression being the most frequent cause of death. Survival differed significantly between the main types of B cell lymphoma. Conclusion. Patients with SS-HCV and B cell lymphoma are clinically characterized by a high frequency of parotid enlargement and vasculitis, an immunologic pattern overwhelmingly dominated by the presence of RF and mixed type II cryoglobulins, a predominance of MALT lymphomas, and an elevated frequency of primary extranodal involvement in organs in which HCV replicates (exocrine glands, liver, and stomach).

Original languageEnglish
Pages (from-to)161-170
Number of pages10
JournalArthritis Care and Research
Volume57
Issue number1
DOIs
Publication statusPublished - Feb 15 2007

Keywords

  • Cryoglobulinemia
  • Hepatitis C virus
  • Lymphoma
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Rheumatology

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  • Cite this

    Ramos-Casals, M., La Civita, L. L. A., De Vita, S., Solans, R., Luppi, M., Medina, F., Caramaschi, P., Fadda, P., De Marchi, G., Lopez-Guillermo, A., Font, J., Brito-Zerón, P., Loustaud-Ratti, V., Zeher, M., Szodoray, P., Bosch, J. A., Selva-O'Callaghan, A., Vilardell, M., Toussirot, E., ... Jara, L. J. (2007). Characterization of B cell lymphoma in patients with Sjögren's syndrome and hepatitis C virus infection. Arthritis Care and Research, 57(1), 161-170. https://doi.org/10.1002/art.22476