Characterization and drug delivery behaviour of starch-based hydrogels prepared via isostatic ultrahigh pressure

Anikó Szepes, Zsolt Makai, Christoph Blümer, Karsten Mäder, Péter Kása, P. Szabó-Révész

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The purpose of our study was to investigate the applicability of isostatic ultra high pressure (IUHP) for the aim of drug formulation. Aqueous suspensions of potato and maize starches containing theophylline as a model drug were subjected to IUHP. The changes in the structure and morphology of potato and maize starches were investigated. The release profile of theophylline from the pressurized samples was also studied. The aqueous suspensions subjected to IUHP turned into highly viscous gels. The crystalline structure of maize starch was changed, while PS pressurized in aqueous medium retained its original X-ray pattern. The sample containing potato starch as a gel-forming polymer exhibited faster drug dissolution compared to an aqueous theophylline suspension used as a reference, while the pressurization of maize starch resulted in a gel exhibiting sustained drug release. The results of the dissolution study can be explained with the changes in structure and morphology of the starches caused by IUHP processing and with the different pressure sensitivities of PS and MS.

Original languageEnglish
Pages (from-to)571-578
Number of pages8
JournalCarbohydrate Polymers
Volume72
Issue number4
DOIs
Publication statusPublished - Jun 10 2008

Fingerprint

Hydrogels
hydrocolloids
corn starch
Starch
Drug delivery
theophylline
potato starch
starch
Pressure
drugs
Zea mays
Theophylline
Solanum tuberosum
Pharmaceutical Preparations
Suspensions
Gels
water
drug formulations
gels
starch gels

Keywords

  • Drug dissolution
  • Isostatic ultrahigh pressure
  • Scanning electron microscopy
  • Starch
  • X-ray diffraction

ASJC Scopus subject areas

  • Food Science
  • Biochemistry

Cite this

Characterization and drug delivery behaviour of starch-based hydrogels prepared via isostatic ultrahigh pressure. / Szepes, Anikó; Makai, Zsolt; Blümer, Christoph; Mäder, Karsten; Kása, Péter; Szabó-Révész, P.

In: Carbohydrate Polymers, Vol. 72, No. 4, 10.06.2008, p. 571-578.

Research output: Contribution to journalArticle

Szepes, Anikó ; Makai, Zsolt ; Blümer, Christoph ; Mäder, Karsten ; Kása, Péter ; Szabó-Révész, P. / Characterization and drug delivery behaviour of starch-based hydrogels prepared via isostatic ultrahigh pressure. In: Carbohydrate Polymers. 2008 ; Vol. 72, No. 4. pp. 571-578.
@article{cd2d03e19ee9484f858d488081869d28,
title = "Characterization and drug delivery behaviour of starch-based hydrogels prepared via isostatic ultrahigh pressure",
abstract = "The purpose of our study was to investigate the applicability of isostatic ultra high pressure (IUHP) for the aim of drug formulation. Aqueous suspensions of potato and maize starches containing theophylline as a model drug were subjected to IUHP. The changes in the structure and morphology of potato and maize starches were investigated. The release profile of theophylline from the pressurized samples was also studied. The aqueous suspensions subjected to IUHP turned into highly viscous gels. The crystalline structure of maize starch was changed, while PS pressurized in aqueous medium retained its original X-ray pattern. The sample containing potato starch as a gel-forming polymer exhibited faster drug dissolution compared to an aqueous theophylline suspension used as a reference, while the pressurization of maize starch resulted in a gel exhibiting sustained drug release. The results of the dissolution study can be explained with the changes in structure and morphology of the starches caused by IUHP processing and with the different pressure sensitivities of PS and MS.",
keywords = "Drug dissolution, Isostatic ultrahigh pressure, Scanning electron microscopy, Starch, X-ray diffraction",
author = "Anik{\'o} Szepes and Zsolt Makai and Christoph Bl{\"u}mer and Karsten M{\"a}der and P{\'e}ter K{\'a}sa and P. Szab{\'o}-R{\'e}v{\'e}sz",
year = "2008",
month = "6",
day = "10",
doi = "10.1016/j.carbpol.2007.09.028",
language = "English",
volume = "72",
pages = "571--578",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Characterization and drug delivery behaviour of starch-based hydrogels prepared via isostatic ultrahigh pressure

AU - Szepes, Anikó

AU - Makai, Zsolt

AU - Blümer, Christoph

AU - Mäder, Karsten

AU - Kása, Péter

AU - Szabó-Révész, P.

PY - 2008/6/10

Y1 - 2008/6/10

N2 - The purpose of our study was to investigate the applicability of isostatic ultra high pressure (IUHP) for the aim of drug formulation. Aqueous suspensions of potato and maize starches containing theophylline as a model drug were subjected to IUHP. The changes in the structure and morphology of potato and maize starches were investigated. The release profile of theophylline from the pressurized samples was also studied. The aqueous suspensions subjected to IUHP turned into highly viscous gels. The crystalline structure of maize starch was changed, while PS pressurized in aqueous medium retained its original X-ray pattern. The sample containing potato starch as a gel-forming polymer exhibited faster drug dissolution compared to an aqueous theophylline suspension used as a reference, while the pressurization of maize starch resulted in a gel exhibiting sustained drug release. The results of the dissolution study can be explained with the changes in structure and morphology of the starches caused by IUHP processing and with the different pressure sensitivities of PS and MS.

AB - The purpose of our study was to investigate the applicability of isostatic ultra high pressure (IUHP) for the aim of drug formulation. Aqueous suspensions of potato and maize starches containing theophylline as a model drug were subjected to IUHP. The changes in the structure and morphology of potato and maize starches were investigated. The release profile of theophylline from the pressurized samples was also studied. The aqueous suspensions subjected to IUHP turned into highly viscous gels. The crystalline structure of maize starch was changed, while PS pressurized in aqueous medium retained its original X-ray pattern. The sample containing potato starch as a gel-forming polymer exhibited faster drug dissolution compared to an aqueous theophylline suspension used as a reference, while the pressurization of maize starch resulted in a gel exhibiting sustained drug release. The results of the dissolution study can be explained with the changes in structure and morphology of the starches caused by IUHP processing and with the different pressure sensitivities of PS and MS.

KW - Drug dissolution

KW - Isostatic ultrahigh pressure

KW - Scanning electron microscopy

KW - Starch

KW - X-ray diffraction

UR - http://www.scopus.com/inward/record.url?scp=40049108721&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40049108721&partnerID=8YFLogxK

U2 - 10.1016/j.carbpol.2007.09.028

DO - 10.1016/j.carbpol.2007.09.028

M3 - Article

VL - 72

SP - 571

EP - 578

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

IS - 4

ER -