Characterization and decomposition of voltage-activated ionic currents using a fitting numerical method

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5 Citations (Scopus)

Abstract

The application of a computer-based numerical method for fast determination of the kinetic parameters of voltage-activated ionic currents is described. Currents with different kinetics and ionic backgrounds are fitted satisfactorily with Hodgkin-Huxley-like functions, and multicomponent currents are decomposed. The method offers a way to separate ionic-current components without pharmacological isolation.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalJournal of Neuroscience Methods
Volume51
Issue number2
DOIs
Publication statusPublished - Mar 1994

Keywords

  • Hodgkin-Huxley equation
  • Kinetic parameter
  • Levenberg-Marquard method
  • Voltage-activated current

ASJC Scopus subject areas

  • Neuroscience(all)

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