Characterization and decomposition of voltage-activated ionic currents using a fitting numerical method

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Abstract

The application of a computer-based numerical method for fast determination of the kinetic parameters of voltage-activated ionic currents is described. Currents with different kinetics and ionic backgrounds are fitted satisfactorily with Hodgkin-Huxley-like functions, and multicomponent currents are decomposed. The method offers a way to separate ionic-current components without pharmacological isolation.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalJournal of Neuroscience Methods
Volume51
Issue number2
DOIs
Publication statusPublished - 1994

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Pharmacology

Keywords

  • Hodgkin-Huxley equation
  • Kinetic parameter
  • Levenberg-Marquard method
  • Voltage-activated current

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Characterization and decomposition of voltage-activated ionic currents using a fitting numerical method",
abstract = "The application of a computer-based numerical method for fast determination of the kinetic parameters of voltage-activated ionic currents is described. Currents with different kinetics and ionic backgrounds are fitted satisfactorily with Hodgkin-Huxley-like functions, and multicomponent currents are decomposed. The method offers a way to separate ionic-current components without pharmacological isolation.",
keywords = "Hodgkin-Huxley equation, Kinetic parameter, Levenberg-Marquard method, Voltage-activated current",
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AB - The application of a computer-based numerical method for fast determination of the kinetic parameters of voltage-activated ionic currents is described. Currents with different kinetics and ionic backgrounds are fitted satisfactorily with Hodgkin-Huxley-like functions, and multicomponent currents are decomposed. The method offers a way to separate ionic-current components without pharmacological isolation.

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