Characteristics of the renin-angiotension-aldosterone system (RAAS) in physiologic pregnancy

M. Nemeth, E. Sulyok, I. Tenyi, I. Csaba

Research output: Contribution to journalArticle


The pathogenetic factors responsible for the hyperfunction of RAAS occurring in physiologic pregnancy, the anatomical structures playing a role in the hyperfunction, as well as the clinical importance of the RAAS's increased function are discussed. On the basis of the literature data and their own experiences the author state that in pregnancy - besides the increased renin-substrate production induced by estrogen, the sodio-uretic effect of certain hormones, the sodio-sequestration occurring in feto-placentary unity and the peculiar change of the renal functions - also the increase of endogenous prostaglandin production are responsible for the RAAS's increased production. To the RAAS's hyperfunction the primary role is attributed in the maintenance of the equilibrium of the maternal water and electrolyte metabolism, as well as in covering the electrolyte and volume requirement of the rapidly increasing foetal water spaces.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
Issue number3
Publication statusPublished - Jan 1 1978

ASJC Scopus subject areas

  • Medicine(all)

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