Matrixmetalloproteinázok (MMP) aktivitásának vizsgálata különbözo malignitású petefészekrákok progressziójában

Translated title of the contribution: Characteristics of ovarian tumors

Attila Demeter, Katalin Szirmai, András Szánthó, Gábor Pogány, Ferenc Tímár, Lászlóné Oláh, András Jeney

Research output: Contribution to journalArticle

Abstract

Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) gelatinolytic activity was analysed in 13 patients with epithelial ovarian cancer, 3 patients with low malignant potential ovarian tumors (LMP), 4 patients with benign ovarian tumors, and in 2 patients with sex-cord stromal ovarian tumors. The authors compared the clinico-pathologic characteristics and prognostic factors of the ovarian tumors with the MMP-activities. Median MMP-2 and MMP-9 activity were higher in epithelial ovarian cancer than in benign ovarian tumors. Median pro-MMP-9 activity was the highest in epithelial ovarian cancer, and median MMP-2 activity was highest in LMP ovarian tumors. The median MMP-9 activity was markedly elevated in advanced-stage and poorly-differentiated ovarian cancer compared to early-stage and well-differentiated ovarian malignancy. This relationship was not observed with regard to MMP-2 activity. Interestingly the highest median MMP-2 and MMP-9 activity were measured in LMP ovarian tumor which may emphasises the separate entity of these tumors. Both MMP-2 and MMP-9 gelatinolytic activity appear in epithelial ovarian tumors, but there is a tendency to express more MMP-9. The poorer the clinico-pathological prognostic factors in ovarian cancer, the higher the median MMP-9 activity was observed.

Translated title of the contributionCharacteristics of ovarian tumors
Original languageHungarian
Pages (from-to)123-129
Number of pages7
JournalMagyar Noorvosok Lapja
Volume66
Issue number2
Publication statusPublished - Jan 1 2003

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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