Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) gelatinolytic activity was analysed in 13 patients with epithelial ovarian cancer, 3 patients with low malignant potential ovarian tumors (LMP), 4 patients with benign ovarian tumors, and in 2 patients with sex-cord stromal ovarian tumors. The authors compared the clinico-pathologic characteristics and prognostic factors of the ovarian tumors with the MMP-activities. Median MMP-2 and MMP-9 activity were higher in epithelial ovarian cancer than in benign ovarian tumors. Median pro-MMP-9 activity was the highest in epithelial ovarian cancer, and median MMP-2 activity was highest in LMP ovarian tumors. The median MMP-9 activity was markedly elevated in advanced-stage and poorly-differentiated ovarian cancer compared to early-stage and well-differentiated ovarian malignancy. This relationship was not observed with regard to MMP-2 activity. Interestingly the highest median MMP-2 and MMP-9 activity were measured in LMP ovarian tumor which may emphasises the separate entity of these tumors. Both MMP-2 and MMP-9 gelatinolytic activity appear in epithelial ovarian tumors, but there is a tendency to express more MMP-9. The poorer the clinico-pathological prognostic factors in ovarian cancer, the higher the median MMP-9 activity was observed.
|Translated title of the contribution||Characteristics of ovarian tumors|
|Number of pages||7|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Jan 1 2003|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology