Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis

Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database

Jerome Avouac, Ulrich Walker, Alan Tyndall, André Kahan, Marco Matucci-Cerinic, Yannick Allanore, I. Miniati, A. Müller, F. Iannone, R. Giacomelli, O. Distler, R. Becvar, S. Sierakowsky, O. Kowal-Bielecka, P. Coelho, J. Cabane, M. Cutolo, Y. Shoenfeld, G. Valentini, J. Rovensky & 160 others G. Riemekasten, I. Nicoara, P. Vlachoyiannopoulos, R. Caporali, S. Jiri, M. Inanc, I. Zimmermann Gorska, P. Carreira, S. Novak, L. Czirják, F. Oliveira Ramos, M. Jendro, C. Chizzolini, E. J. Kucharz, J. Richter, F. Cozzi, B. Rozman, C. M. Mallia, A. Gabrielli, D. Farge, H. P. Kiener, D. Schöffel, M. Sticherling, P. Airo, F. Wollheim, D. Martinovic, F. Trotta, N. Hunzelmann, S. Jablonska, K. Reich, S. Bombardieri, P. Siakka, R. Pellerito, L. M. Bambara, J. Morovic-Vergles, C. Denton, R. Hinrichs, F. Van Den Hoogen, N. Damjanov, I. Kötter, V. Ortiz, S. Heitmann, D. Krasowska, M. Seidel, P. Hasler, J. M. Van Laar, J. P. Kaltwasser, I. Foeldvari, A. Juan Mas, G. Bajocchi, M. Wislowska, J. A. Pereira Da Silva, S. Jacobsen, M. Worm, W. Graniger, A. Kuhn, A. Stankovic, R. Cossutta, M. Majdan, L. Damjanovska Rajcevska, M. Tikly, E. L. Nasonov, K. Steinbrink, A. Herrick, U. Müller-Ladner, A. Dinc, R. Scorza, K. Sondergaard, F. Indiveri, H. Nielsen, Z. Szekanecz, R. M. Silver, M. Antivalle, I. B. Espinosa, P. García De La Pena Lefebvre, O. Midtvedt, D. Launay, F. Valesini, P. Tuvik, R. M. Ionescu, N. Del Papa, S. Pinto, F. Wigley, C. Mihai, M. Sinziana Capranu, C. Sunderkötter, J. B. Jun, C. Derk, S. Alhasani, J. H. Distler, E. Ton, T. Soukup, J. Seibold, S. Zeni, P. Nash, L. Mouthon, F. De Keyser, M. T. Duruöz, F. P. Cantatore, G. Strauss, C. A. Von Mülhen, M. R. Pozzi, K. Eyerich, J. Szechinski, M. Keiserman, F. A. Houssiau, J. A. Rom-Ivorra, B. Krummel-Lorenz, M. Aringer, R. Westhovens, F. Bellisai, M. Mayer, F. Stoeckl, M. Üprus, A. Volpe, M. Buslau, S. Yavuz, B. Granel, A. Valderílio Feijó, F. Del Galdo, S. Popa, T. Zenone, X. Ricardo Machado, M. Pileckyte, S. Stebbings, A. Mathieu, A. Tulli, T. Tourinho, R. Souza, R. Acayaba De Toledo, L. Stamp, K. Solanki, D. Veale, J. Francisco Marques Neto, G. F. Bagnato, E. Loyo, S. Toloza, M. Li, W. Ahmed Abdel Atty Mohamed, V. Cobankara, J. Olas, F. Salsano, F. Oksel, C. M. Tanaseanu, R. Foti, C. Ancuta, M. Vonk, P. Caramashi, L. Beretta, A. Balbir, B. Shine, A. Chiàla, K. Pasalic Simic, M. Ghio, B. Stamenkovic, S. Rednic, N. Host, R. Pellerito, E. Hachulla, D. E. Furst

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Objective. To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc). Methods. This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs. Results. We recruited 7286 patients with SSc; their mean age was 56 ± 14 years, disease duration 10 ± 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable. Conclusion. Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with amore severe disease and with systemic inflammation. The Journal of Rheumatology

Original languageEnglish
Pages (from-to)1488-1501
Number of pages14
JournalJournal of Rheumatology
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Systemic Scleroderma
Rheumatic Diseases
Joints
Databases
Inflammation
Synovitis
Friction
Tendons
Research
Contracture
Acute-Phase Proteins
Rheumatology
Articular Range of Motion
Skin Diseases
Blood Vessels
Registries
Cross-Sectional Studies
Kidney

Keywords

  • Joint contracture
  • Joint involvement
  • Synovitis
  • Systemic sclerosis
  • Tendon friction rub

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis : Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database. / Avouac, Jerome; Walker, Ulrich; Tyndall, Alan; Kahan, André; Matucci-Cerinic, Marco; Allanore, Yannick; Miniati, I.; Müller, A.; Iannone, F.; Giacomelli, R.; Distler, O.; Becvar, R.; Sierakowsky, S.; Kowal-Bielecka, O.; Coelho, P.; Cabane, J.; Cutolo, M.; Shoenfeld, Y.; Valentini, G.; Rovensky, J.; Riemekasten, G.; Nicoara, I.; Vlachoyiannopoulos, P.; Caporali, R.; Jiri, S.; Inanc, M.; Gorska, I. Zimmermann; Carreira, P.; Novak, S.; Czirják, L.; Ramos, F. Oliveira; Jendro, M.; Chizzolini, C.; Kucharz, E. J.; Richter, J.; Cozzi, F.; Rozman, B.; Mallia, C. M.; Gabrielli, A.; Farge, D.; Kiener, H. P.; Schöffel, D.; Sticherling, M.; Airo, P.; Wollheim, F.; Martinovic, D.; Trotta, F.; Hunzelmann, N.; Jablonska, S.; Reich, K.; Bombardieri, S.; Siakka, P.; Pellerito, R.; Bambara, L. M.; Morovic-Vergles, J.; Denton, C.; Hinrichs, R.; Van Den Hoogen, F.; Damjanov, N.; Kötter, I.; Ortiz, V.; Heitmann, S.; Krasowska, D.; Seidel, M.; Hasler, P.; Van Laar, J. M.; Kaltwasser, J. P.; Foeldvari, I.; Juan Mas, A.; Bajocchi, G.; Wislowska, M.; Pereira Da Silva, J. A.; Jacobsen, S.; Worm, M.; Graniger, W.; Kuhn, A.; Stankovic, A.; Cossutta, R.; Majdan, M.; Rajcevska, L. Damjanovska; Tikly, M.; Nasonov, E. L.; Steinbrink, K.; Herrick, A.; Müller-Ladner, U.; Dinc, A.; Scorza, R.; Sondergaard, K.; Indiveri, F.; Nielsen, H.; Szekanecz, Z.; Silver, R. M.; Antivalle, M.; Espinosa, I. B.; García De La Pena Lefebvre, P.; Midtvedt, O.; Launay, D.; Valesini, F.; Tuvik, P.; Ionescu, R. M.; Del Papa, N.; Pinto, S.; Wigley, F.; Mihai, C.; Capranu, M. Sinziana; Sunderkötter, C.; Jun, J. B.; Derk, C.; Alhasani, S.; Distler, J. H.; Ton, E.; Soukup, T.; Seibold, J.; Zeni, S.; Nash, P.; Mouthon, L.; De Keyser, F.; Duruöz, M. T.; Cantatore, F. P.; Strauss, G.; Von Mülhen, C. A.; Pozzi, M. R.; Eyerich, K.; Szechinski, J.; Keiserman, M.; Houssiau, F. A.; Rom-Ivorra, J. A.; Krummel-Lorenz, B.; Aringer, M.; Westhovens, R.; Bellisai, F.; Mayer, M.; Stoeckl, F.; Üprus, M.; Volpe, A.; Buslau, M.; Yavuz, S.; Granel, B.; Feijó, A. Valderílio; Del Galdo, F.; Popa, S.; Zenone, T.; Machado, X. Ricardo; Pileckyte, M.; Stebbings, S.; Mathieu, A.; Tulli, A.; Tourinho, T.; Souza, R.; Acayaba De Toledo, R.; Stamp, L.; Solanki, K.; Veale, D.; Neto, J. Francisco Marques; Bagnato, G. F.; Loyo, E.; Toloza, S.; Li, M.; Mohamed, W. Ahmed Abdel Atty; Cobankara, V.; Olas, J.; Salsano, F.; Oksel, F.; Tanaseanu, C. M.; Foti, R.; Ancuta, C.; Vonk, M.; Caramashi, P.; Beretta, L.; Balbir, A.; Shine, B.; Chiàla, A.; Simic, K. Pasalic; Ghio, M.; Stamenkovic, B.; Rednic, S.; Host, N.; Pellerito, R.; Hachulla, E.; Furst, D. E.

In: Journal of Rheumatology, Vol. 37, No. 7, 07.2010, p. 1488-1501.

Research output: Contribution to journalArticle

Avouac, J, Walker, U, Tyndall, A, Kahan, A, Matucci-Cerinic, M, Allanore, Y, Miniati, I, Müller, A, Iannone, F, Giacomelli, R, Distler, O, Becvar, R, Sierakowsky, S, Kowal-Bielecka, O, Coelho, P, Cabane, J, Cutolo, M, Shoenfeld, Y, Valentini, G, Rovensky, J, Riemekasten, G, Nicoara, I, Vlachoyiannopoulos, P, Caporali, R, Jiri, S, Inanc, M, Gorska, IZ, Carreira, P, Novak, S, Czirják, L, Ramos, FO, Jendro, M, Chizzolini, C, Kucharz, EJ, Richter, J, Cozzi, F, Rozman, B, Mallia, CM, Gabrielli, A, Farge, D, Kiener, HP, Schöffel, D, Sticherling, M, Airo, P, Wollheim, F, Martinovic, D, Trotta, F, Hunzelmann, N, Jablonska, S, Reich, K, Bombardieri, S, Siakka, P, Pellerito, R, Bambara, LM, Morovic-Vergles, J, Denton, C, Hinrichs, R, Van Den Hoogen, F, Damjanov, N, Kötter, I, Ortiz, V, Heitmann, S, Krasowska, D, Seidel, M, Hasler, P, Van Laar, JM, Kaltwasser, JP, Foeldvari, I, Juan Mas, A, Bajocchi, G, Wislowska, M, Pereira Da Silva, JA, Jacobsen, S, Worm, M, Graniger, W, Kuhn, A, Stankovic, A, Cossutta, R, Majdan, M, Rajcevska, LD, Tikly, M, Nasonov, EL, Steinbrink, K, Herrick, A, Müller-Ladner, U, Dinc, A, Scorza, R, Sondergaard, K, Indiveri, F, Nielsen, H, Szekanecz, Z, Silver, RM, Antivalle, M, Espinosa, IB, García De La Pena Lefebvre, P, Midtvedt, O, Launay, D, Valesini, F, Tuvik, P, Ionescu, RM, Del Papa, N, Pinto, S, Wigley, F, Mihai, C, Capranu, MS, Sunderkötter, C, Jun, JB, Derk, C, Alhasani, S, Distler, JH, Ton, E, Soukup, T, Seibold, J, Zeni, S, Nash, P, Mouthon, L, De Keyser, F, Duruöz, MT, Cantatore, FP, Strauss, G, Von Mülhen, CA, Pozzi, MR, Eyerich, K, Szechinski, J, Keiserman, M, Houssiau, FA, Rom-Ivorra, JA, Krummel-Lorenz, B, Aringer, M, Westhovens, R, Bellisai, F, Mayer, M, Stoeckl, F, Üprus, M, Volpe, A, Buslau, M, Yavuz, S, Granel, B, Feijó, AV, Del Galdo, F, Popa, S, Zenone, T, Machado, XR, Pileckyte, M, Stebbings, S, Mathieu, A, Tulli, A, Tourinho, T, Souza, R, Acayaba De Toledo, R, Stamp, L, Solanki, K, Veale, D, Neto, JFM, Bagnato, GF, Loyo, E, Toloza, S, Li, M, Mohamed, WAAA, Cobankara, V, Olas, J, Salsano, F, Oksel, F, Tanaseanu, CM, Foti, R, Ancuta, C, Vonk, M, Caramashi, P, Beretta, L, Balbir, A, Shine, B, Chiàla, A, Simic, KP, Ghio, M, Stamenkovic, B, Rednic, S, Host, N, Pellerito, R, Hachulla, E & Furst, DE 2010, 'Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database', Journal of Rheumatology, vol. 37, no. 7, pp. 1488-1501. https://doi.org/10.3899/jrheum.091165
Avouac, Jerome ; Walker, Ulrich ; Tyndall, Alan ; Kahan, André ; Matucci-Cerinic, Marco ; Allanore, Yannick ; Miniati, I. ; Müller, A. ; Iannone, F. ; Giacomelli, R. ; Distler, O. ; Becvar, R. ; Sierakowsky, S. ; Kowal-Bielecka, O. ; Coelho, P. ; Cabane, J. ; Cutolo, M. ; Shoenfeld, Y. ; Valentini, G. ; Rovensky, J. ; Riemekasten, G. ; Nicoara, I. ; Vlachoyiannopoulos, P. ; Caporali, R. ; Jiri, S. ; Inanc, M. ; Gorska, I. Zimmermann ; Carreira, P. ; Novak, S. ; Czirják, L. ; Ramos, F. Oliveira ; Jendro, M. ; Chizzolini, C. ; Kucharz, E. J. ; Richter, J. ; Cozzi, F. ; Rozman, B. ; Mallia, C. M. ; Gabrielli, A. ; Farge, D. ; Kiener, H. P. ; Schöffel, D. ; Sticherling, M. ; Airo, P. ; Wollheim, F. ; Martinovic, D. ; Trotta, F. ; Hunzelmann, N. ; Jablonska, S. ; Reich, K. ; Bombardieri, S. ; Siakka, P. ; Pellerito, R. ; Bambara, L. M. ; Morovic-Vergles, J. ; Denton, C. ; Hinrichs, R. ; Van Den Hoogen, F. ; Damjanov, N. ; Kötter, I. ; Ortiz, V. ; Heitmann, S. ; Krasowska, D. ; Seidel, M. ; Hasler, P. ; Van Laar, J. M. ; Kaltwasser, J. P. ; Foeldvari, I. ; Juan Mas, A. ; Bajocchi, G. ; Wislowska, M. ; Pereira Da Silva, J. A. ; Jacobsen, S. ; Worm, M. ; Graniger, W. ; Kuhn, A. ; Stankovic, A. ; Cossutta, R. ; Majdan, M. ; Rajcevska, L. Damjanovska ; Tikly, M. ; Nasonov, E. L. ; Steinbrink, K. ; Herrick, A. ; Müller-Ladner, U. ; Dinc, A. ; Scorza, R. ; Sondergaard, K. ; Indiveri, F. ; Nielsen, H. ; Szekanecz, Z. ; Silver, R. M. ; Antivalle, M. ; Espinosa, I. B. ; García De La Pena Lefebvre, P. ; Midtvedt, O. ; Launay, D. ; Valesini, F. ; Tuvik, P. ; Ionescu, R. M. ; Del Papa, N. ; Pinto, S. ; Wigley, F. ; Mihai, C. ; Capranu, M. Sinziana ; Sunderkötter, C. ; Jun, J. B. ; Derk, C. ; Alhasani, S. ; Distler, J. H. ; Ton, E. ; Soukup, T. ; Seibold, J. ; Zeni, S. ; Nash, P. ; Mouthon, L. ; De Keyser, F. ; Duruöz, M. T. ; Cantatore, F. P. ; Strauss, G. ; Von Mülhen, C. A. ; Pozzi, M. R. ; Eyerich, K. ; Szechinski, J. ; Keiserman, M. ; Houssiau, F. A. ; Rom-Ivorra, J. A. ; Krummel-Lorenz, B. ; Aringer, M. ; Westhovens, R. ; Bellisai, F. ; Mayer, M. ; Stoeckl, F. ; Üprus, M. ; Volpe, A. ; Buslau, M. ; Yavuz, S. ; Granel, B. ; Feijó, A. Valderílio ; Del Galdo, F. ; Popa, S. ; Zenone, T. ; Machado, X. Ricardo ; Pileckyte, M. ; Stebbings, S. ; Mathieu, A. ; Tulli, A. ; Tourinho, T. ; Souza, R. ; Acayaba De Toledo, R. ; Stamp, L. ; Solanki, K. ; Veale, D. ; Neto, J. Francisco Marques ; Bagnato, G. F. ; Loyo, E. ; Toloza, S. ; Li, M. ; Mohamed, W. Ahmed Abdel Atty ; Cobankara, V. ; Olas, J. ; Salsano, F. ; Oksel, F. ; Tanaseanu, C. M. ; Foti, R. ; Ancuta, C. ; Vonk, M. ; Caramashi, P. ; Beretta, L. ; Balbir, A. ; Shine, B. ; Chiàla, A. ; Simic, K. Pasalic ; Ghio, M. ; Stamenkovic, B. ; Rednic, S. ; Host, N. ; Pellerito, R. ; Hachulla, E. ; Furst, D. E. / Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis : Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database. In: Journal of Rheumatology. 2010 ; Vol. 37, No. 7. pp. 1488-1501.
@article{8295fe708ab845e787fab7e2fc217d00,
title = "Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database",
abstract = "Objective. To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc). Methods. This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs. Results. We recruited 7286 patients with SSc; their mean age was 56 ± 14 years, disease duration 10 ± 9 years, and 4210 (58{\%}) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16{\%}, 11{\%}, and 31{\%}, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable. Conclusion. Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with amore severe disease and with systemic inflammation. The Journal of Rheumatology",
keywords = "Joint contracture, Joint involvement, Synovitis, Systemic sclerosis, Tendon friction rub",
author = "Jerome Avouac and Ulrich Walker and Alan Tyndall and Andr{\'e} Kahan and Marco Matucci-Cerinic and Yannick Allanore and I. Miniati and A. M{\"u}ller and F. Iannone and R. Giacomelli and O. Distler and R. Becvar and S. Sierakowsky and O. Kowal-Bielecka and P. Coelho and J. Cabane and M. Cutolo and Y. Shoenfeld and G. Valentini and J. Rovensky and G. Riemekasten and I. Nicoara and P. Vlachoyiannopoulos and R. Caporali and S. Jiri and M. Inanc and Gorska, {I. Zimmermann} and P. Carreira and S. Novak and L. Czirj{\'a}k and Ramos, {F. Oliveira} and M. Jendro and C. Chizzolini and Kucharz, {E. J.} and J. Richter and F. Cozzi and B. Rozman and Mallia, {C. M.} and A. Gabrielli and D. Farge and Kiener, {H. P.} and D. Sch{\"o}ffel and M. Sticherling and P. Airo and F. Wollheim and D. Martinovic and F. Trotta and N. Hunzelmann and S. Jablonska and K. Reich and S. Bombardieri and P. Siakka and R. Pellerito and Bambara, {L. M.} and J. Morovic-Vergles and C. Denton and R. Hinrichs and {Van Den Hoogen}, F. and N. Damjanov and I. K{\"o}tter and V. Ortiz and S. Heitmann and D. Krasowska and M. Seidel and P. Hasler and {Van Laar}, {J. M.} and Kaltwasser, {J. P.} and I. Foeldvari and {Juan Mas}, A. and G. Bajocchi and M. Wislowska and {Pereira Da Silva}, {J. A.} and S. Jacobsen and M. Worm and W. Graniger and A. Kuhn and A. Stankovic and R. Cossutta and M. Majdan and Rajcevska, {L. Damjanovska} and M. Tikly and Nasonov, {E. L.} and K. Steinbrink and A. Herrick and U. M{\"u}ller-Ladner and A. Dinc and R. Scorza and K. Sondergaard and F. Indiveri and H. Nielsen and Z. Szekanecz and Silver, {R. M.} and M. Antivalle and Espinosa, {I. B.} and {Garc{\'i}a De La Pena Lefebvre}, P. and O. Midtvedt and D. Launay and F. Valesini and P. Tuvik and Ionescu, {R. M.} and {Del Papa}, N. and S. Pinto and F. Wigley and C. Mihai and Capranu, {M. Sinziana} and C. Sunderk{\"o}tter and Jun, {J. B.} and C. Derk and S. Alhasani and Distler, {J. H.} and E. Ton and T. Soukup and J. Seibold and S. Zeni and P. Nash and L. Mouthon and {De Keyser}, F. and Duru{\"o}z, {M. T.} and Cantatore, {F. P.} and G. Strauss and {Von M{\"u}lhen}, {C. A.} and Pozzi, {M. R.} and K. Eyerich and J. Szechinski and M. Keiserman and Houssiau, {F. A.} and Rom-Ivorra, {J. A.} and B. Krummel-Lorenz and M. Aringer and R. Westhovens and F. Bellisai and M. Mayer and F. Stoeckl and M. {\"U}prus and A. Volpe and M. Buslau and S. Yavuz and B. Granel and Feij{\'o}, {A. Valder{\'i}lio} and {Del Galdo}, F. and S. Popa and T. Zenone and Machado, {X. Ricardo} and M. Pileckyte and S. Stebbings and A. Mathieu and A. Tulli and T. Tourinho and R. Souza and {Acayaba De Toledo}, R. and L. Stamp and K. Solanki and D. Veale and Neto, {J. Francisco Marques} and Bagnato, {G. F.} and E. Loyo and S. Toloza and M. Li and Mohamed, {W. Ahmed Abdel Atty} and V. Cobankara and J. Olas and F. Salsano and F. Oksel and Tanaseanu, {C. M.} and R. Foti and C. Ancuta and M. Vonk and P. Caramashi and L. Beretta and A. Balbir and B. Shine and A. Chi{\`a}la and Simic, {K. Pasalic} and M. Ghio and B. Stamenkovic and S. Rednic and N. Host and R. Pellerito and E. Hachulla and Furst, {D. E.}",
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}

TY - JOUR

T1 - Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis

T2 - Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database

AU - Avouac, Jerome

AU - Walker, Ulrich

AU - Tyndall, Alan

AU - Kahan, André

AU - Matucci-Cerinic, Marco

AU - Allanore, Yannick

AU - Miniati, I.

AU - Müller, A.

AU - Iannone, F.

AU - Giacomelli, R.

AU - Distler, O.

AU - Becvar, R.

AU - Sierakowsky, S.

AU - Kowal-Bielecka, O.

AU - Coelho, P.

AU - Cabane, J.

AU - Cutolo, M.

AU - Shoenfeld, Y.

AU - Valentini, G.

AU - Rovensky, J.

AU - Riemekasten, G.

AU - Nicoara, I.

AU - Vlachoyiannopoulos, P.

AU - Caporali, R.

AU - Jiri, S.

AU - Inanc, M.

AU - Gorska, I. Zimmermann

AU - Carreira, P.

AU - Novak, S.

AU - Czirják, L.

AU - Ramos, F. Oliveira

AU - Jendro, M.

AU - Chizzolini, C.

AU - Kucharz, E. J.

AU - Richter, J.

AU - Cozzi, F.

AU - Rozman, B.

AU - Mallia, C. M.

AU - Gabrielli, A.

AU - Farge, D.

AU - Kiener, H. P.

AU - Schöffel, D.

AU - Sticherling, M.

AU - Airo, P.

AU - Wollheim, F.

AU - Martinovic, D.

AU - Trotta, F.

AU - Hunzelmann, N.

AU - Jablonska, S.

AU - Reich, K.

AU - Bombardieri, S.

AU - Siakka, P.

AU - Pellerito, R.

AU - Bambara, L. M.

AU - Morovic-Vergles, J.

AU - Denton, C.

AU - Hinrichs, R.

AU - Van Den Hoogen, F.

AU - Damjanov, N.

AU - Kötter, I.

AU - Ortiz, V.

AU - Heitmann, S.

AU - Krasowska, D.

AU - Seidel, M.

AU - Hasler, P.

AU - Van Laar, J. M.

AU - Kaltwasser, J. P.

AU - Foeldvari, I.

AU - Juan Mas, A.

AU - Bajocchi, G.

AU - Wislowska, M.

AU - Pereira Da Silva, J. A.

AU - Jacobsen, S.

AU - Worm, M.

AU - Graniger, W.

AU - Kuhn, A.

AU - Stankovic, A.

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PY - 2010/7

Y1 - 2010/7

N2 - Objective. To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc). Methods. This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs. Results. We recruited 7286 patients with SSc; their mean age was 56 ± 14 years, disease duration 10 ± 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable. Conclusion. Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with amore severe disease and with systemic inflammation. The Journal of Rheumatology

AB - Objective. To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc). Methods. This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs. Results. We recruited 7286 patients with SSc; their mean age was 56 ± 14 years, disease duration 10 ± 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable. Conclusion. Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with amore severe disease and with systemic inflammation. The Journal of Rheumatology

KW - Joint contracture

KW - Joint involvement

KW - Synovitis

KW - Systemic sclerosis

KW - Tendon friction rub

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UR - http://www.scopus.com/inward/citedby.url?scp=77954436578&partnerID=8YFLogxK

U2 - 10.3899/jrheum.091165

DO - 10.3899/jrheum.091165

M3 - Article

VL - 37

SP - 1488

EP - 1501

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 7

ER -