Characteristics of cystic breast disease with special regard to breast cancer development

B. Budai, I. Számel, Z. Sulyok, M. Német, M. Bak, Sz Ottó, M. J. Reed, A. Purohit, D. C. Parish, J. Kralovánszky

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background. This prospective study compares the characteristics of cystic disease of the breast (CDB) of patients who developed breast cancer (BCa) during the follow-up (1.25-4 years) period with those who did not. Materials and methods: K+, Na+, albumin, dehydroepiandrosterone (DHA), DHA-sulphate, oestrone, oestradiol, testosterone and progesterone levels were determined in breast cyst fluid (BCF). Patients presented data about their menstrual status, reproductive history, lactation period, date of first and the number of BCF aspirations, gynaecological interventions, use of oral contraceptives, family history of cancer, smoking habits and coffee consumption. The BCa incidence of patients was compared with the expected number of BCas in an age-matched group of 5143 women. Results: Out of 147 patients 6 developed BCa. The standardized incidence rate was 6.29. There were significant differences in testosterone, oestrone and progesterone levels and also reproductive history of patients who developed BCa compared with patients without BCa. Conclusion: The above markers outline a subgroup of patients with the highest BCa risk.

Original languageEnglish
Pages (from-to)749-752
Number of pages4
JournalAnticancer Research
Volume21
Issue number1 B
Publication statusPublished - 2001

Fingerprint

Fibrocystic Breast Disease
Breast Neoplasms
Reproductive History
Breast Cyst
Cyst Fluid
Estrone
Progesterone
Testosterone
Dehydroepiandrosterone Sulfate
Dehydroepiandrosterone
Coffee
Incidence
Oral Contraceptives
Lactation
Habits
Albumins
Estradiol
Research Design
Age Groups
Smoking

Keywords

  • Breast cancer incidence
  • Breast cyst fluid
  • Reproductive history
  • Steroid hormones

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Budai, B., Számel, I., Sulyok, Z., Német, M., Bak, M., Ottó, S., ... Kralovánszky, J. (2001). Characteristics of cystic breast disease with special regard to breast cancer development. Anticancer Research, 21(1 B), 749-752.

Characteristics of cystic breast disease with special regard to breast cancer development. / Budai, B.; Számel, I.; Sulyok, Z.; Német, M.; Bak, M.; Ottó, Sz; Reed, M. J.; Purohit, A.; Parish, D. C.; Kralovánszky, J.

In: Anticancer Research, Vol. 21, No. 1 B, 2001, p. 749-752.

Research output: Contribution to journalArticle

Budai, B, Számel, I, Sulyok, Z, Német, M, Bak, M, Ottó, S, Reed, MJ, Purohit, A, Parish, DC & Kralovánszky, J 2001, 'Characteristics of cystic breast disease with special regard to breast cancer development', Anticancer Research, vol. 21, no. 1 B, pp. 749-752.
Budai, B. ; Számel, I. ; Sulyok, Z. ; Német, M. ; Bak, M. ; Ottó, Sz ; Reed, M. J. ; Purohit, A. ; Parish, D. C. ; Kralovánszky, J. / Characteristics of cystic breast disease with special regard to breast cancer development. In: Anticancer Research. 2001 ; Vol. 21, No. 1 B. pp. 749-752.
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