Chapter 7 Transcriptome alterations in schizophrenia: disturbing the functional architecture of the dorsolateral prefrontal cortex

David A. Lewis, K. Mirnics

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The availability of methods for quantifying tissue concentrations of messenger RNAs in the postmortem of the human brain has provided a number of new findings in schizophrenia. However, understanding how these findings actually relate to the disease process of schizophrenia requires knowledge both of the factors that might give rise to such changes in gene expression and of the impact of these changes on the function of the affected neural circuits. Consequently, this chapter provides a review of the potential causes and consequences of some of the schizophrenia-related transcriptome changes in the dorsolateral prefrontal cortex, a brain region implicated in the pathophysiology of certain core cognitive deficits in this illness.

Original languageEnglish
Pages (from-to)141-152
Number of pages12
JournalProgress in Brain Research
Volume158
DOIs
Publication statusPublished - 2006

Fingerprint

Prefrontal Cortex
Transcriptome
Schizophrenia
Brain
Gene Expression
Messenger RNA

Keywords

  • GABA
  • glutamic acid decarboxylase
  • prefrontal cortex
  • regulator of G-protein signaling 4
  • schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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