Migraine is a highly prevalent, disabling primary headache disorder which has a high socioeconomic impact. Its pathomechanism involves peripheral and central sensitization processes and activation of the trigeminovascular system. Alterations in the glutamatergic neurotransmission and the activation of excitatory receptors leading to neuronal hyperexcitability have been implicated in the pathomechanism of different pain syndromes, including migraine and neuropathic pain. The pharmacological management of these disorders is often a challenge, and the identifi cation of possible new druggable targets is therefore at the focus of research interest. The kynurenine pathway involves several neuroactive metabolites which can infl uence glutamatergic neurotransmission and may therefore be promising novel candidates for drug development.
- Kynurenic acid
- Kynurenine pathway
- Neuropathic pain
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)