Chapter 18: The role of kynurenine pathway in pain and migraine

Zsófi A. Majláth, J. Toldi, L. Vécsei

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Migraine is a highly prevalent, disabling primary headache disorder which has a high socioeconomic impact. Its pathomechanism involves peripheral and central sensitization processes and activation of the trigeminovascular system. Alterations in the glutamatergic neurotransmission and the activation of excitatory receptors leading to neuronal hyperexcitability have been implicated in the pathomechanism of different pain syndromes, including migraine and neuropathic pain. The pharmacological management of these disorders is often a challenge, and the identifi cation of possible new druggable targets is therefore at the focus of research interest. The kynurenine pathway involves several neuroactive metabolites which can infl uence glutamatergic neurotransmission and may therefore be promising novel candidates for drug development.

Original languageEnglish
Title of host publicationTargeting the Broadly Pathogenic Kynurenine Pathway
PublisherSpringer International Publishing
Pages233-240
Number of pages8
ISBN (Print)9783319118703, 9783319118697
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Glutamate
  • Hyperexcitability
  • Kynurenic acid
  • Kynurenine pathway
  • Migraine
  • Neuropathic pain
  • Nociception

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Neuroscience(all)

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    Majláth, Z. A., Toldi, J., & Vécsei, L. (2015). Chapter 18: The role of kynurenine pathway in pain and migraine. In Targeting the Broadly Pathogenic Kynurenine Pathway (pp. 233-240). Springer International Publishing. https://doi.org/10.1007/978-3-319-11870-3_18