Chapter 15: The role of the kynurenine pathway in neurodegenerative diseases

Zsófi A. Majláth, J. Toldi, L. Vécsei

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The kynurenine pathway, the main metabolic route of tryptophan degradation, produces several neuroactive molecules. Alterations in the kynurenine pathway have been described in a number of neurological disorders; a feature of special importance is the elevation of neurotoxic metabolites, which may promote glutamate- mediated excitotoxic neuronal damage. The delicate balance between the neurotoxic and neuroprotective compounds participating in the kynurenine pathway has been suggested to play an important role in the regulation of glutamatergic neurotransmission and in infl ammatory processes. Synthetic kynurenic acid derivatives and kynurenine-monooxygenase inhibitors have proved in several preclinical studies to have benefi cial effects. The kynurenine pathway offers a promising target for future drug development with the aim of achieving neuroprotection.

Original languageEnglish
Title of host publicationTargeting the Broadly Pathogenic Kynurenine Pathway
PublisherSpringer International Publishing
Pages193-204
Number of pages12
ISBN (Print)9783319118703, 9783319118697
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Amyotrophic lateral sclerosis
  • Huntington’s disease
  • Kynurenine pathway
  • Multiple sclerosis
  • Neurodegenerative disorders
  • Neuroprotection
  • Parkinson’s disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Chapter 15: The role of the kynurenine pathway in neurodegenerative diseases'. Together they form a unique fingerprint.

  • Cite this

    Majláth, Z. A., Toldi, J., & Vécsei, L. (2015). Chapter 15: The role of the kynurenine pathway in neurodegenerative diseases. In Targeting the Broadly Pathogenic Kynurenine Pathway (pp. 193-204). Springer International Publishing. https://doi.org/10.1007/978-3-319-11870-3_15