Chaperones as parts of cellular networks

P. Csermely, C. Söti, Gregory L. Blatch

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The most important interactions between cellular molecules have a high affinity, are unique and specific, and require a network approach for a detailed description. Molecular chaperones usually have many first and second neighbors in protein-protein interaction networks and they play a prominent role in signaling and transcriptional regulatory networks of the cell. Chaperones may uncouple protein, signaling, membranous, organellar and transcriptional networks during stress, which gives an additional protection for the cell at the network-level. Recent advances uncovered that chaperones act as genetic buffers stabilizing the phenotype of various cells and organisms. This chaperone effect on the emergent properties of cellular networks may be generalized to proteins having a specific, central position and low affinity, weak links in protein networks. Cellular networks are preferentially remodeled in various diseases and aging, which may help us to design novel therapeutic and anti-aging strategies.

Original languageEnglish
Pages (from-to)55-63
Number of pages9
JournalAdvances in Experimental Medicine and Biology
Volume594
DOIs
Publication statusPublished - 2007

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Gene Regulatory Networks
Protein Interaction Maps
Proteins
Molecular Chaperones
Cytoprotection
Aging of materials
Buffers
Phenotype
Molecules
Therapeutics
link protein

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Chaperones as parts of cellular networks. / Csermely, P.; Söti, C.; Blatch, Gregory L.

In: Advances in Experimental Medicine and Biology, Vol. 594, 2007, p. 55-63.

Research output: Contribution to journalArticle

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