Chaperones as part of immune networks

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Network theory is increasingly accepted as a basic regulatory mechanism in diverse immunological functions. Heat shock proteins (Hsps) are involved in multiple networks in the immune system. Hsps themselves (foreign or endogenous) activate innate immunity and play important roles to deliver self or nonself materials to antigen presenting cells. However, Hsps are immunodominant antigens during infectious diseases making self Hsps endangered targets of autoimmunity by cross-reactive clones. Therefore, it is not surprising that the mechanism of protection of self Hsps is not clonal deletion in natural self tolerance; rather, self Hsps are protected by active regulating natural autoimmunity. The active regulatory/protective immunity is accomplished by natural autoantibodies and regulatory T cells, both recognizing Hsps. The multiple involvements of Hsps in immune networks make them ideal targets of therapy in autoimmune diseases. Indeed, immunotherapy with Hsps was recently reported to be effective treatment modality against cancer, arthritis or diabetes mellitus.

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalAdvances in Experimental Medicine and Biology
Volume594
DOIs
Publication statusPublished - 2007

Fingerprint

Heat-Shock Proteins
Autoimmunity
Clonal Deletion
Self Tolerance
Immunodominant Epitopes
T-cells
Immune system
Circuit theory
Antigen-Presenting Cells
Regulatory T-Lymphocytes
Medical problems
Innate Immunity
Autoantibodies
Immunotherapy
Autoimmune Diseases
Arthritis
Communicable Diseases
Immune System
Immunity
Diabetes Mellitus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Chaperones as part of immune networks. / Prohászka, Z.

In: Advances in Experimental Medicine and Biology, Vol. 594, 2007, p. 159-166.

Research output: Contribution to journalArticle

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